TY - JOUR
T1 - Polycystic ovary syndrome or hyperprolactinaemia
T2 - A study of mild hyperprolactinaemia
AU - Su, Hung Wen
AU - Chen, Ching-Min
AU - Chou, Szu-Yuan
AU - Liang, So Jung
AU - Hsu, Chun-Sen
AU - Hsu, Ming I.
PY - 2011/1
Y1 - 2011/1
N2 - Polycystic ovary syndrome (PCOS) and hyperprolactinaemia are both common causes of secondary amenorrhoea in reproductive women. The relationship between PCOS and hyperprolactinaemia has been reported with controversial results. To evaluate the clinical and laboratory features of women with mild hyperprolactinaemia and PCOS, we studied 474 Taiwan Chinese women: 101 had mild hyperprolactinaemia, 266 had PCOS and 107 were the control group. In this study, we found that 64% of the women with mild hyperprolactinaemia fulfilled the PCOS diagnostic criteria, regardless of their prolactin levels. Obese women with PCOS had significantly lower luteinising hormone (LH) and LH-to-FSH ratios than non-obese women with PCOS. Obese hyperprolactinaemic women had significantly lower follicle-stimulating hormone (FSH), but higher LH-to-FSH ratios than the non-obese hyperprolactinaemic women. For women with PCOS, the BMIs were significantly negative with LH (γ = -0.253, p <0.001), but not with FSH (γ = -0.061, p = 0.319). For the hyperprolactinaemic women, the BMIs were significantly negative with FSH (γ = -0.353, p
AB - Polycystic ovary syndrome (PCOS) and hyperprolactinaemia are both common causes of secondary amenorrhoea in reproductive women. The relationship between PCOS and hyperprolactinaemia has been reported with controversial results. To evaluate the clinical and laboratory features of women with mild hyperprolactinaemia and PCOS, we studied 474 Taiwan Chinese women: 101 had mild hyperprolactinaemia, 266 had PCOS and 107 were the control group. In this study, we found that 64% of the women with mild hyperprolactinaemia fulfilled the PCOS diagnostic criteria, regardless of their prolactin levels. Obese women with PCOS had significantly lower luteinising hormone (LH) and LH-to-FSH ratios than non-obese women with PCOS. Obese hyperprolactinaemic women had significantly lower follicle-stimulating hormone (FSH), but higher LH-to-FSH ratios than the non-obese hyperprolactinaemic women. For women with PCOS, the BMIs were significantly negative with LH (γ = -0.253, p <0.001), but not with FSH (γ = -0.061, p = 0.319). For the hyperprolactinaemic women, the BMIs were significantly negative with FSH (γ = -0.353, p
KW - FSH
KW - LH
KW - LH-to-FSH ratio
KW - Polycystic ovary syndrome
KW - hyperprolactinaemia
KW - obese
KW - polycystic ovaries
UR - http://www.scopus.com/inward/record.url?scp=78650168212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650168212&partnerID=8YFLogxK
U2 - 10.3109/09513590.2010.487606
DO - 10.3109/09513590.2010.487606
M3 - Article
C2 - 20504100
AN - SCOPUS:78650168212
SN - 0951-3590
VL - 27
SP - 55
EP - 62
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 1
ER -
