Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies

Tai Li Tsou, Shang Tao Tang, Yu Chuan Huang, Jing Ran Wu, Jenn Jong Young, Hsian Jenn Wang

研究成果: 雜誌貢獻文章同行評審

66 引文 斯高帕斯(Scopus)


An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0 ≤ F ≤ 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.

頁(從 - 到)95-100
期刊Journal of Materials Science: Materials in Medicine
出版狀態已發佈 - 2月 2005

ASJC Scopus subject areas

  • 生物物理學
  • 生物工程
  • 生物材料
  • 生物醫學工程


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