Podophyllotoxin intoxication: Toxic effect of Bajiaolian in herbal therapeutics

W. F. Kao, D. Z. Hung, W. J. Tsai, K. P. Lin, J. F. Deng

研究成果: 雜誌貢獻文章同行評審

89 引文 斯高帕斯(Scopus)


Bajiaolian (Dysosma pleianthum), one species in the Mayapple family, has been widely used as a general remedy and for the treatment of snake bite, weakness, condyloma accuminata, lymphadenopathy and tumours in China for thousands of years. However, the textbooks of traditional Chinese medicine mention little about the toxicity of Bajiaolian. Within 1 year, the authors saw five people who manifested nausea, vomiting, diarrhoea, abdominal pain, thrombocytopenia, leucopenia, abnormal liver function tests, sensory ataxia, altered consciousness and persistant peripheral tingling or numbness after drinking infusions made with Bajiaolian. The herb was recommended by either traditional Chinese medical doctors or herbal pharmacies for postpartum recovery and treatment of a neck mass, hepatoma, lumbago and dysmenorrhoea. Podophyllotoxin is one of the main ingredients of the Bajiaolian root. The clinical manifestations observed in our patients were consistent with podophyllum intoxication. Podophyllotoxin intoxication usually results from the accidental ingestion or topical application of podophyllum resin. However, these cases of Bajiaolian intoxication were iatrogenic and results from 'therapeutic doses' of Bajiaolian cited in the textbooks of traditional Chinese medicine.

頁(從 - 到)480-487
期刊Human and Experimental Toxicology
出版狀態已發佈 - 1992

ASJC Scopus subject areas

  • 毒理學
  • 健康、毒理學和誘變


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