Plumbagin Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress-related Cell Apoptosis in Human Oral Squamous Cell Carcinoma

Po Han Chen, Hsein Kun Lu, Ting Yi Renn, Tsung Ming Chang, Chia Jung Lee, Ya Ting Tsao, Po Kai Chuang, Ju Fang Liu

研究成果: 雜誌貢獻文章同行評審

摘要

Background/Aim: Oral squamous cell carcinoma (OSCC), a major malignancy in Taiwan, is an invasive epithelial neoplasm resulting in a low survival rate. Current treatments do not prevent OSCC progression, and antitumor therapies should be improved. Plumbagin, a natural compound extracted from Plumbago zeylanica L., appears to have antitumor effects in various tumors. The antitumor mechanism of plumbagin in OSCC is still unclear. This study investigated the molecular mechanism through which plumbagin induces apoptosis. Materials and Methods: To investigate the antiproliferative and pro-apoptotic effects of Plumbagin on OSCC cells and explore its underlying mechanism, cell counting kit-8, cell cycle analysis, and annexin V/PI assay were conducted. The functions of plumbagin on endoplasmic reticulum (ER) stress, reactive oxygen species (ROS).
原文英語
頁(從 - 到)1173-1182
頁數10
期刊Anticancer Research
44
發行號3
DOIs
出版狀態已發佈 - 3月 2024

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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