TY - JOUR
T1 - Plectranthus amboinicus and Centella asiatica cream for the treatment of diabetic foot ulcers
AU - Kuo, Yuan-Sung
AU - Chien, Hsiung-Fei
AU - Lu, William
N1 - Export Date: 16 March 2016
通訊地址: Chien, H.-F.; Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan; 電子郵件: [email protected]
商標: AQUACEL; Opsite, Smith and Nephew, Taiwan
製造商: Smith and Nephew, Taiwan
參考文獻: Frykberg, R.G., Diabetic foot ulcers: Pathogenesis and management (2002) American Family Physician, 66 (9), pp. 1655-1662; Bader, M.S., Diabetic foot infection (2008) American Family Physician, 78 (1), pp. 71-79; Reiber, G.E., Smith, D.G., Vileikyte, L., Lavery, L.A., Boyko, E.J., Boulton, A.J.M., Del Aguila, M., Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings (1999) Diabetes Care, 22 (1), pp. 157-162. , DOI 10.2337/diacare.22.1.157; Frykberg, R.G., Wittmayer, B., Zgonis, T., Surgical Management of Diabetic Foot Infections and Osteomyelitis (2007) Clinics in Podiatric Medicine and Surgery, 24 (3), pp. 469-482. , DOI 10.1016/j.cpm.2007.04.001, PII S0891842207000316, Advances in the Treatment of the Diabetic Foot; Lipsky, B.A., Berendt, A.R., Deery, H.G., Embil, J.M., Joseph, W.S., Karchmer, A.W., LeFrock, J.L., Tan, J.S., Diagnosis and treatment of diabetic foot infections (2004) Clinical Infectious Diseases, 39 (7), pp. 885-910. , DOI 10.1086/424846; Lipsky, B.A., Armstrong, D.G., Citron, D.M., Tice, A.D., Morgenstern, D.E., Abramson, M.A., Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): Prospective, randomised, controlled, double-blinded, multicentre trial (2005) Lancet, 366 (9498), pp. 1695-1703. , DOI 10.1016/S0140-6736(05)67694-5, PII S0140673605676945; Lipsky, B.A., Giordano, P., Choudhri, S., Song, J., Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/ amoxicillin-clavulanate (2007) Journal of Antimicrobial Chemotherapy, 60 (2), pp. 370-376. , DOI 10.1093/jac/dkm130; Nagoba, B.S., Gandhi, R.C., Wadher, B.J., Rao, A., Hartalkar, A.R., Selkar, S.P., A simple and effective approach for the treatment of diabetic foot ulcers with different Wagner grades (2010) International Wound Journal, 7 (3), pp. 153-158; Chen, L.C., Wang, B.R., Chou, Y.C., Tien, J.H., Drug utilization pattern of Chinese herbal medicines in a general hospital in Taiwan (2005) Pharmacoepidemiology and Drug Safety, 14 (9), pp. 651-657. , DOI 10.1002/pds.1087; Lukhoba, C.W., Simmonds, M.S.J., Paton, A.J., Plectranthus: A review of ethnobotanical uses (2006) Journal of Ethnopharmacology, 103 (1), pp. 1-24. , DOI 10.1016/j.jep.2005.09.011, PII S0378874105006215; Gurgel, A.P.A.D., Da Silva, J.G., Grangeiro, A.R.S., Oliveira, D.C., Lima, C.M.P., Da Silva, A.C.P., Oliveira, R.A.G., Souza, I.A., In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae) (2009) Journal of Ethnopharmacology, 125 (2), pp. 361-363; Chiu, Y.J., Huang, T.H., Chiu, C.S., Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. Both in vitro and in vivo (2012) Evidence-Based Complementary and Alternative Medicine, 2012, p. 11; Shukla, A., Rasik, A.M., Jain, G.K., Shankar, R., Kulshrestha, D.K., Dhawan, B.N., In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica (1999) Journal of Ethnopharmacology, 65 (1), pp. 1-11. , DOI 10.1016/S0378-8741(98)00141-X, PII S037887419800141X; Brinkhaus, B., Lindner, M., Schuppan, D., Hahn, E.G., Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica (2000) Phytomedicine, 7 (5), pp. 427-448; Piaggesi, A., Baccetti, F., Rizzo, L., Romanelli, M., Navalesi, R., Benzi, L., Sodium carboxyl-methyl-cellulose dressings in the management of deep ulcerations of diabetic foot (2001) Diabetic Medicine, 18 (4), pp. 320-324. , DOI 10.1046/j.1464-5491.2001.00466.x; Jeffcoate, W.J., Price, P.E., Phillips, C.J., Game, F.L., Mudge, E., Davies, S., Amery, C.M., Harding, K.G., Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes (2009) Health Technology Assessment, 13 (54), pp. 1-86; Brown-Etris, M., Milne, C., Orsted, H., Gates, J.L., Netsch, D., Punchello, M., Couture, N., Freyberg, J., A prospective, randomized, multisite clinical evaluation of a transparent absorbent acrylic dressing and a hydrocolloid dressing in the management of Stage II and shallow Stage III pressure ulcers (2008) Advances in Skin Wound Care, 21 (4), pp. 169-174; Ernst, E., Cardiovascular adverse effects of herbal medicines: A systematic review of the recent litarature (2003) Canadian Journal of Cardiology, 19 (7), pp. 818-827; Ernst, E., Herbal medicines: Balancing benefits and risks (2007) Novartis Foundation Symposium, 282, pp. 154-167; Lavery, L.A., Armstrong, D.G., Harkless, L.B., Classification of diabetic foot wounds (1996) Journal of Foot and Ankle Surgery, 35 (6), pp. 528-531; Mustoe, T.A., Cutler, N.R., Allman, R.M., Goode, P.S., Deuel, T.F., Prause, J.A., Bear, M., Pierce, G.F., A phase II study to evaluate recombinant platelet-derived growth factor- BB in the treatment of stage 3 and 4 pressure ulcers (1994) Archives of Surgery, 129 (2), pp. 213-219; Wieman, T.J., Smiell, J.M., Su, Y., Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: A phase III randomized placebo-controlled double-blind study (1998) Diabetes Care, 21 (5), pp. 822-827. , DOI 10.2337/diacare.21.5.822; Shukrimi, A., Sulaiman, A.R., Halim, A.Y., Azril, A., A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers (2008) Medical Journal of Malaysia, 63 (1), pp. 44-46
PY - 2012
Y1 - 2012
N2 - Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright © 2012 Yuan-Sung Kuo et al.
AB - Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright © 2012 Yuan-Sung Kuo et al.
KW - Centella asiatica extract
KW - opsite
KW - plant extract
KW - Plectranthus amboinicus extract
KW - unclassified drug
KW - adult
KW - aged
KW - article
KW - Centella asiatica
KW - clinical article
KW - constipation
KW - controlled study
KW - cream
KW - debridement
KW - diabetic foot
KW - dizziness
KW - drug dosage form comparison
KW - female
KW - human
KW - hydrocolloid dressing
KW - hypoglycemia
KW - insulin dependent diabetes mellitus
KW - male
KW - non insulin dependent diabetes mellitus
KW - Plectranthus
KW - Plectranthus amboinicus
KW - priority journal
KW - randomized controlled trial
KW - safety
KW - tinea pedis
KW - visual field defect
KW - wound dressing
U2 - 10.1155/2012/418679
DO - 10.1155/2012/418679
M3 - Article
SN - 1741-427X
VL - 2012
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
ER -