Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis; Shaker A. Mousa; Geraldine P. Schechter; Hung Yun Lin

doi:10.1007/s12672-019-00371-4

Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis, Shaker A. Mousa, Geraldine P. Schechter, Hung Yun Lin

研究成果: 雜誌貢獻 › 回顧型文獻 › 同行評審

16 引文斯高帕斯（Scopus）

摘要

Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

原文	英語
頁（從 - 到）	13-16
頁數	4
期刊	Hormones and Cancer
卷	11
發行號	1
DOIs	https://doi.org/10.1007/s12672-019-00371-4
出版狀態	已發佈 - 2月 1 2020

ASJC Scopus subject areas

內分泌學、糖尿病和代謝
腫瘤科
內分泌
內分泌和自主系統
癌症研究

UN SDG

此研究成果有助於以下永續發展目標

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10.1007/s12672-019-00371-4

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引用此

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title = "Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis",

abstract = "Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.",

keywords = "3,5,3′-Triiodo-L-thyronine (T3), Degranulation, Integrin, L-Thyroxine (T4), Metastasis, Thyroid hormone receptors, Tumor cell invasiveness",

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AU - Davis, Paul J.

AU - Mousa, Shaker A.

AU - Schechter, Geraldine P.

AU - Lin, Hung Yun

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

AB - Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

KW - 3,5,3′-Triiodo-L-thyronine (T3)

KW - Degranulation

KW - Integrin

KW - L-Thyroxine (T4)

KW - Metastasis

KW - Thyroid hormone receptors

KW - Tumor cell invasiveness

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U2 - 10.1007/s12672-019-00371-4

DO - 10.1007/s12672-019-00371-4

M3 - Review article

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AN - SCOPUS:85076528718

SN - 1868-8497

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JO - Hormones and Cancer

JF - Hormones and Cancer

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Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

摘要

ASJC Scopus subject areas

UN SDG

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