Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma

Wei Shu Wang, Jen Kou Lin, Tzu Chen Lin, Tzeon Jye Chiou, Jin Hwang Liu, Chueh Chuan Yen, Po Min Chen

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69 引文 斯高帕斯(Scopus)

摘要

Aim: To evaluate the correlations of plasma von Willebrand factor (vWF) level with the distant metastasis and prognosis of patients with colorectal cancer. Methods: A total of 86 patients with histologically confirmed metastatic colorectal cancers receiving treatment at Taipei Veterans General Hospital were enrolled. All patients had measurable metastatic lesions and life expectancies of more than 3 mo. Plasma vWF levels were measured by immuno-turbidimetric assay and compared with results from 40 non-metastatic colorectal cancer patients and 22 healthy controls. Patients with metastatic colorectal cancer were divided into two groups according to serum vWF levels and the differences between these two groups were analyzed using χ2 test. Data on age, gender, performance status, location of primary tumor, extent of metastasis, site of metastases, histological differentiation, serum CEA and plasma vWF levels were analyzed to determine association with survival. Survival curves were constructed by Kaplan-Meier product limit method and the data was analyzed using log-rank test on a microcomputer. Multivariate analysis using the Cox's proportional hazards regression model was then performed to determine the independent prognostic indicators among all of the possible variables. Results: Colorectal cancer patients were identified as having significantly higher plasma vWF concentrations than healthy controls (P
原文英語
頁(從 - 到)2166-2170
頁數5
期刊World Journal of Gastroenterology
11
發行號14
DOIs
出版狀態已發佈 - 4月 2005
對外發佈

ASJC Scopus subject areas

  • 消化內科

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