TY - JOUR
T1 - Plasma fractionation issues
AU - Farrugia, Albert
AU - Evers, Theo
AU - Falcou, Pierre Francois
AU - Burnouf, Thierry
AU - Amorim, Luiz
AU - Thomas, Sylvia
PY - 2009/4
Y1 - 2009/4
N2 - Procurement and processing of human plasma for fractionation of therapeutic proteins or biological medicines used in clinical practice is a multi-billion dollar international trade. Together the private sector and public sector (non-profit) provide large amounts of safe and effective therapeutic plasma proteins needed worldwide. The principal therapeutic proteins produced by the dichotomous industry include gamma globulins or immunoglobulins (including pathogen-specific hyperimmune globulins, such as hepatitis B immune globulins) albumin, factor VIII and Factor IX concentrates. Viral inactivation, principally by solvent detergent and other processes, has proven highly effective in preventing transmission of enveloped viruses, viz. HBV, HIV, and HCV.
AB - Procurement and processing of human plasma for fractionation of therapeutic proteins or biological medicines used in clinical practice is a multi-billion dollar international trade. Together the private sector and public sector (non-profit) provide large amounts of safe and effective therapeutic plasma proteins needed worldwide. The principal therapeutic proteins produced by the dichotomous industry include gamma globulins or immunoglobulins (including pathogen-specific hyperimmune globulins, such as hepatitis B immune globulins) albumin, factor VIII and Factor IX concentrates. Viral inactivation, principally by solvent detergent and other processes, has proven highly effective in preventing transmission of enveloped viruses, viz. HBV, HIV, and HCV.
KW - Factor VIII
KW - IVIG
KW - Procurement of plasma
KW - Protein fractionation
KW - Viral inactivation
UR - http://www.scopus.com/inward/record.url?scp=63249113806&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63249113806&partnerID=8YFLogxK
U2 - 10.1016/j.biologicals.2009.01.005
DO - 10.1016/j.biologicals.2009.01.005
M3 - Article
C2 - 19289290
AN - SCOPUS:63249113806
SN - 1045-1056
VL - 37
SP - 88
EP - 93
JO - Journal of Biological Standardization
JF - Journal of Biological Standardization
IS - 2
ER -
