Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics

Chia Hung Liu, Ming Che Liu, Pei Ru Jheng, Jiashing Yu, Yu Jui Fan, Jia Wei Liang, Yu Cheng Hsiao, Chih Wei Chiang, Nima Bolouki, Jyh Wei Lee, Jang Hsing Hsieh, Bradley W. Mansel, Yan Ting Chen, Hieu Trung Nguyen, Er Yuan Chuang

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11 引文 斯高帕斯(Scopus)

摘要

Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment.
原文英語
文章編號2301504
期刊Advanced healthcare materials
12
發行號28
DOIs
出版狀態已發佈 - 11月 10 2023

ASJC Scopus subject areas

  • 生物材料
  • 生物醫學工程
  • 藥學科學

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