摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 280-289 |
頁數 | 10 |
期刊 | International Journal of Biochemistry and Cell Biology |
卷 | 44 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 2012 |
對外發佈 | 是 |
指紋
深入研究「Pigment epithelium-derived factor reduces the PDGF-induced migration and proliferation of human aortic smooth muscle cells through PPARγ activation」主題。共同形成了獨特的指紋。引用此
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於: International Journal of Biochemistry and Cell Biology, 卷 44, 編號 2, 2012, p. 280-289.
研究成果: 雜誌貢獻 › 文章 › 同行評審
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TY - JOUR
T1 - Pigment epithelium-derived factor reduces the PDGF-induced migration and proliferation of human aortic smooth muscle cells through PPARγ activation
AU - Wang, Shu-Huei
AU - Liang, Chan-Jung
AU - Wu, Jiahn-Chun
AU - Huang, Jiuan-Jiuan
AU - Chien, Hsiung-Fei
AU - Tsai, Jaw-Shiun
AU - Yen, Yuh-Siu
AU - Tseng, Ying-Chih
AU - Lue, June-Horng
AU - Chen, Yuh-Lien
N1 - 被引用次數:6 Export Date: 16 March 2016 CODEN: IJBBF 通訊地址: Lue, J.-H.; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan; 電子郵件: [email protected] 化學物質/CAS: cyclin dependent kinase 2, 141349-86-2; cyclin dependent kinase 4, 147014-97-9; pigment epithelium derived factor, 197980-93-1; Eye Proteins; Nerve Growth Factors; PPAR gamma; Platelet-Derived Growth Factor; Serpins; pigment epithelium-derived factor 參考文獻: Abe, R., Fujita, Y., Yamagishi, S., Shimizu, H., Pigment epithelium-derived factor prevents melanoma growth via angiogenesis inhibition (2008) Curr Pharm des, 14, pp. 3802-3809; Andres, V., Castro, C., Antiproliferative strategies for the treatment of vascular proliferative disease (2003) Curr Vasc Pharmacol, 1, pp. 85-98; Bardot, O., Aldridge, T.C., Latruffe, N., Green, S., PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene (1993) Biochemical and Biophysical Research Communications, 192 (1), pp. 37-45. , DOI 10.1006/bbrc.1993.1378; Benson, S., Wu, J., Padmanabhan, S., Kurtz, T.W., Pershadsingh, H.A., Peroxisome proliferator-activated receptor (PPAR)-γ expression in human vascular smooth muscle cells: Inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-γ activator troglitazone (2000) American Journal of Hypertension, 13 (1), pp. 74-82. , DOI 10.1016/S0895-7061(99)00148-X, PII S089570619900148X; Bishop-Bailey, D., Hla, T., Endothelial cell apoptosis induced by the peroxisome proliferator- activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2 (1999) J Biol Chem, 274, pp. 17042-17048; Broadhead, M.L., Dass, C.R., Choong, P.F., Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma model (2011) Br J Cancer, pp. 1-9; Charron, T., Nili, N., Strauss, B.H., The cell cycle: A critical therapeutic target to prevent vascular proliferative disease (2006) Canadian Journal of Cardiology, 22 (SUPPL. 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Ghosh, S.S., Gehr, T.W.B., Ghosh, S., Fakhry, I., Sica, D.A., Lyall, V., Schoolwerth, A.C., PPARγ ligand attenuates PDGF-induced mesangial cell proliferation: Role of MAP kinase (2003) Kidney International, 64 (1), pp. 52-62. , DOI 10.1046/j.1523-1755.2003.00054.x; Goetze, S., Xi, X.-P., Kawano, H., Gotlibowski, T., Fleck, E., Hsueh, W.A., Law, R.E., PPARγ-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells (1999) Journal of Cardiovascular Pharmacology, 33 (5), pp. 798-806. , DOI 10.1097/00005344-199905000-00018; Hamblin, M., Chang, L., Fan, Y., Zhang, J., Chen, Y.E., PPARs and the cardiovascular system (2009) Antioxid Redox Signal, 11, pp. 1415-1452; Hirsch, J., Johnson, C.L., Nelius, T., Kennedy, R., Riese, W., Filleur, S., PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor/phospholipase A2 and regulation of NF κb and PPARγ (2011) Cytokine, 55, pp. 202-210; Hoshina, D., Abe, R., Yamagishi, S.I., Shimizu, H., The role of PEDF in tumor growth and metastasis (2010) Curr Mol Med, 10, pp. 292-295; Ho, T.C., Chen, S.L., Yang, Y.C., Liao, C.L., Cheng, H.C., Tsao, Y.P., PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells (2007) Cardiovasc Res, 76, pp. 213-223; Ho, T.C., Yang, Y.C., Chen, S.L., Kuo, P.C., Sytwu, H.K., Cheng, H.C., Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma (2008) Mol Immunol, 45, pp. 898-909; Jiang, H.Y., Petrovas, C., Sonenshein, G.E., Relb-p50 NF-κB complexes are selectively induced by cytomegalovirus immediate-early protein 1: Differential regulation of Bcl-x L promoter activity by NF-κB family members (2002) Journal of Virology, 76 (11), pp. 5737-5747. , DOI 10.1128/JVI.76.11.5737-5747.2002; Law, R.E., Goetze, S., Xi, X.-P., Jackson, S., Kawano, Y., Demer, L., Fishbein, M.C., Hsueh, W.A., Expression and function of PPARγ in rat and human vascular smooth muscle cells (2000) Circulation, 101 (11), pp. 1311-1318; Law, R.E., Meehan, W.P., Xi, X.-P., Graf, K., Wuthrich, D.A., Coats, W., Faxon, D., Hsueh, W.A., Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia (1996) Journal of Clinical Investigation, 98 (8), pp. 1897-1905; Marx, N., Schonbeck, U., Lazar, M.A., Libby, P., Plutzky, J., Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells (1998) Circulation Research, 83 (11), pp. 1097-1103; Nakamura, K., Yamagishi, S.-I., Matsui, T., Yoshida, T., Takenaka, K., Jinnouchi, Y., Yoshida, Y., Imaizumi, T., Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation (2007) American Journal of Pathology, 170 (6), pp. 2159-2170. , DOI 10.2353/ajpath.2007.060838; Notari, L., Baladron, V., Aroca-Aguilar, J.D., Balko, N., Heredia, R., Meyer, C., Notario, P.M., Becerra, S.P., Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor (2006) Journal of Biological Chemistry, 281 (49), pp. 38022-38037. , http://www.jbc.org/cgi/reprint/281/49/38022, DOI 10.1074/jbc.M600353200; Ross, R., The pathogenesis of atherosclerosis: A perspective for the 1990 (1993) Nature, 362, pp. 801-809; Sata, M., Maejima, Y., Adachi, F., Fukino, K., Saiura, A., Sugiura, S., A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia (2000) J Mol Cell Cardiol, 32, pp. 2097-2104; Takenaka, K., Yamagishi, S.-i., Matsui, T., Nakamura, K., Jinnouchi, Y., Yoshida, Y., Ueda, S.-i., Imaizumi, T., Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: A possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes (2008) Atherosclerosis, 197 (1), pp. 25-33. , DOI 10.1016/j.atherosclerosis.2007.07.041, PII S002191500700473X; Tan, M.L., Choong, P.F., Dass, C.R., Anti-chondrosarcoma effects of PEDF mediated via molecules important to apoptosis, cell cycling, adhesion and invasion (2010) Biochem Biophys Res Commun, 398, pp. 613-618; Tombran-Tink, J., Chader, G.G., Johnson, L.V., PEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity (1991) Exp Eye Res, 53, pp. 411-414; Wakino, S., Kintscher, U., Kim, S., Yin, F., Hsueh, W.A., Law, R.E., Peroxisome proliferator-activated receptor γ ligands inhibit retinoblastoma phosphorylation and G 1 → S transition in vascular smooth muscle cells (2000) Journal of Biological Chemistry, 275 (29), pp. 22435-22441. , DOI 10.1074/jbc.M910452199; Wang, S.H., Lin, S.J., Chen, Y.H., Lin, F.Y., Shih, J.C., Wu, C.C., Late outgrowth endothelial cells derived from Wharton jelly in human umbilical cord reduce neointimal formation after vascular injury: Involvement of pigment epithelium-derived factor (2009) Arterioscler Thromb Vasc Biol, 29, pp. 816-822; Yamagishi, S.-I., Inagaki, Y., Nakamura, K., Abe, R., Shimizu, T., Yoshimura, A., Imaizumi, T., Pigment epithelium-derived factor inhibits TNF-α-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation (2004) Journal of Molecular and Cellular Cardiology, 37 (2), pp. 497-506. , DOI 10.1016/j.yjmcc.2004.04.007, PII S0022282804000926; Yamagishi, S.-I., Nakamura, K., Ueda, S., Kato, S., Imaizumi, T., Pigment epithelium-derived factor (PEDF) blocks angiotensin II signaling in endothelial cells via suppression of NADPH oxidase: A novel anti-oxidative mechanism of PEDF (2005) Cell and Tissue Research, 320 (3), pp. 437-445. , DOI 10.1007/s00441-005-1094-8; Yang, S.L., Chen, S.L., Wu, J.Y., Ho, T.C., Tsao, Y.P., Pigment epithelium-derived factor induces interleukin-10 expression in human macrophages by induction of PPAR gamma (2010) Life Sci, 87, pp. 26-35; Zhang, S.X., Wang, J.J., Gao, G., Shao, C., Mott, R., Ma, J.-X., Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor (2006) FASEB Journal, 20 (2), pp. 323-325. , http://www.fasebj.org/cgi/reprint/20/2/323, DOI 10.1096/fj.05-4313fje
PY - 2012
Y1 - 2012
N2 - Our previous study demonstrated that pigment epithelium-derived factor (PEDF) plays an important role in the proliferation and migration of human aortic smooth muscle cells (HASMCs). In the present study, we examined whether PEDF inhibited platelet-derived growth factor (PDGF)-stimulated HASMC migration and proliferation. PEDF dose-dependently reduced PDGF-induced HASMC migration and proliferation in vitro and also arrested cell cycle progression in the G0/G1 phase, and this was associated with decreased expression of cyclin D1, cyclin E, CDK2, CDK4, and p21 Cip1 and increased expression of the cyclin-dependent kinase inhibitor p27 Kip1. The antiproliferative and antimigratory effects of PEDF were partially blocked by the PPARγ antagonist GW9662, but not by the PPARα antagonist MK886. In in vivo studies, the femoral artery of C57BL/6 mice was endothelial-denuded and the mice injected intravenously with PEDF or vehicle. After 2 weeks, both the neointima/media area ratio and cell proliferation (proliferating cell nuclear antigen-positive cells) in the neointima were significantly reduced and again these effects were partially reversed by GW9662 pretreatment. Our data show that PEDF increases PPARγ activation, preventing entry of HASMCs into the cell cycle in vitro and reducing the neointimal area and cell proliferation in the neointima in vivo. Thus, PEDF may represent a safe and effective novel target for the prevention and treatment of vascular proliferative diseases. © 2011 Elsevier Ltd. All rights reserved.
AB - Our previous study demonstrated that pigment epithelium-derived factor (PEDF) plays an important role in the proliferation and migration of human aortic smooth muscle cells (HASMCs). In the present study, we examined whether PEDF inhibited platelet-derived growth factor (PDGF)-stimulated HASMC migration and proliferation. PEDF dose-dependently reduced PDGF-induced HASMC migration and proliferation in vitro and also arrested cell cycle progression in the G0/G1 phase, and this was associated with decreased expression of cyclin D1, cyclin E, CDK2, CDK4, and p21 Cip1 and increased expression of the cyclin-dependent kinase inhibitor p27 Kip1. The antiproliferative and antimigratory effects of PEDF were partially blocked by the PPARγ antagonist GW9662, but not by the PPARα antagonist MK886. In in vivo studies, the femoral artery of C57BL/6 mice was endothelial-denuded and the mice injected intravenously with PEDF or vehicle. After 2 weeks, both the neointima/media area ratio and cell proliferation (proliferating cell nuclear antigen-positive cells) in the neointima were significantly reduced and again these effects were partially reversed by GW9662 pretreatment. Our data show that PEDF increases PPARγ activation, preventing entry of HASMCs into the cell cycle in vitro and reducing the neointimal area and cell proliferation in the neointima in vivo. Thus, PEDF may represent a safe and effective novel target for the prevention and treatment of vascular proliferative diseases. © 2011 Elsevier Ltd. All rights reserved.
KW - Cell cycle
KW - Neointimal hyperplasia
KW - PEDF
KW - PPARγ
KW - Proliferation
KW - 2 chloro 5 nitrobenzanilide
KW - cyclin D1
KW - cyclin dependent kinase 2
KW - cyclin dependent kinase 4
KW - cyclin dependent kinase inhibitor 1
KW - cyclin dependent kinase inhibitor 1B
KW - cyclin E
KW - cycline
KW - peroxisome proliferator activated receptor gamma
KW - pigment epithelium derived factor
KW - platelet derived growth factor
KW - animal experiment
KW - animal model
KW - animal tissue
KW - antiproliferative activity
KW - aorta media
KW - artery intima proliferation
KW - article
KW - blood vessel injury
KW - cell cycle G0 phase
KW - cell cycle progression
KW - cell migration
KW - cell proliferation
KW - concentration response
KW - controlled study
KW - femoral artery
KW - G1 phase cell cycle checkpoint
KW - human
KW - human cell
KW - male
KW - mouse
KW - neointima
KW - nonhuman
KW - protein expression
KW - smooth muscle fiber
KW - Western blotting
KW - Animals
KW - Aorta
KW - Cell Cycle
KW - Cell Movement
KW - Cell Proliferation
KW - Eye Proteins
KW - Humans
KW - Mice
KW - Muscle, Smooth, Vascular
KW - Neointima
KW - Nerve Growth Factors
KW - Platelet-Derived Growth Factor
KW - PPAR gamma
KW - Serpins
KW - Mus
U2 - 10.1016/j.biocel.2011.10.023
DO - 10.1016/j.biocel.2011.10.023
M3 - Article
SN - 1357-2725
VL - 44
SP - 280
EP - 289
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 2
ER -