Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species

Agriculture & Biology

• renal cell carcinoma 67%
• transcription factor NF-kappa B 61%
• apoptosis 38%
• reactive oxygen species 34%
• acetylcysteine 15%
• cells 13%
• Physalis angulata 9%
• caspase-9 8%
• NAD ADP-ribosyltransferase 8%
• caspase-3 7%
• DNA fragmentation 7%
• antineoplastic agents 6%
• cytochrome c 6%
• mitochondrial membrane 6%
• carcinoma 6%
• membrane potential 5%
• interphase 5%
• nuclear genome 5%
• flow cytometry 5%
• cytosol 5%
• chromatin 5%
• cytotoxicity 5%
• cleavage (chemistry) 5%
• glutathione 4%
• mitochondria 4%
• kidneys 4%
• antioxidants 3%
• degradation 3%
• assays 3%
• extracts 3%
• proteins 1%
• methodology 1%

Medicine & Life Sciences

• physalin F 92%
• NF-kappa B 44%
• Renal Cell Carcinoma 39%
• Reactive Oxygen Species 33%
• Apoptosis 25%
• N-acetylglutathione 15%
• Acetylcysteine 10%
• Physalis 8%
• Poly(ADP-ribose) Polymerases 5%
• Caspase 9 5%
• Cytochromes c 4%
• DNA Fragmentation 4%
• Mitochondrial Membrane Potential 4%
• G1 Phase 4%
• Cytosol 4%
• Caspase 3 4%
• Chromatin 4%
• Mitochondria 3%
• Flow Cytometry 3%
• Antioxidants 3%
• Carcinoma 3%
• Kidney 2%
• Proteins 1%
• Neoplasms 1%

Chemical Compounds

• Physalin F 100%
• Physalin 39%
• Reactive Oxygen Metabolite 38%
• N-Acetyl-L-Cysteine 20%
• Poly(ADPribose) 9%
• Membrane Potential 7%
• Cytometry 7%
• Glutathione 6%
• Antineoplastic Agent 6%
• Cytochrome 5%
• Fragmentation 5%
• Antioxidant Agent 5%
• Condensation 5%
• Cleavage 4%
• Flow 4%
• Dioxygen 3%
• Protein 2%