Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

Shih Ming Chen; Mei Yu Fan; Chia Chi Tseng; Yih Ho; Kuang Yang Hsu

doi:10.1016/j.toxicon.2007.03.011

Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

Shih Ming Chen, Mei Yu Fan, Chia Chi Tseng, Yih Ho, Kuang Yang Hsu

研究成果: 雜誌貢獻 › 文章 › 同行評審

28 引文斯高帕斯（Scopus）

摘要

Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. After intravenous administration of different doses (0.25, 0.5, 1.0, and 2.0 mg/kg) of aristolochic acid sodium (AANa) to 4 respective groups of rabbits (n=6 for each dose), linear relationships between the doses of AA I and AA II and the area under the plasma concentration curve (AUC) were found to exist (p

原文	英語
頁（從 - 到）	180-188
頁數	9
期刊	Toxicon
卷	50
發行號	2
DOIs	https://doi.org/10.1016/j.toxicon.2007.03.011
出版狀態	已發佈 - 8月 2007

ASJC Scopus subject areas

毒理學

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10.1016/j.toxicon.2007.03.011

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abstract = "Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. After intravenous administration of different doses (0.25, 0.5, 1.0, and 2.0 mg/kg) of aristolochic acid sodium (AANa) to 4 respective groups of rabbits (n=6 for each dose), linear relationships between the doses of AA I and AA II and the area under the plasma concentration curve (AUC) were found to exist (p",

keywords = "Aristolochic acids nephropathy (AAN), Nephrotoxicity, Pharmacokinetic, Rabbit",

author = "Chen, {Shih Ming} and Fan, {Mei Yu} and Tseng, {Chia Chi} and Yih Ho and Hsu, {Kuang Yang}",

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AU - Fan, Mei Yu

AU - Tseng, Chia Chi

AU - Ho, Yih

AU - Hsu, Kuang Yang

PY - 2007/8

Y1 - 2007/8

N2 - Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. After intravenous administration of different doses (0.25, 0.5, 1.0, and 2.0 mg/kg) of aristolochic acid sodium (AANa) to 4 respective groups of rabbits (n=6 for each dose), linear relationships between the doses of AA I and AA II and the area under the plasma concentration curve (AUC) were found to exist (p

AB - Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. After intravenous administration of different doses (0.25, 0.5, 1.0, and 2.0 mg/kg) of aristolochic acid sodium (AANa) to 4 respective groups of rabbits (n=6 for each dose), linear relationships between the doses of AA I and AA II and the area under the plasma concentration curve (AUC) were found to exist (p

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KW - Pharmacokinetic

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Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

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