@article{4a722538ff7842e891649735725c79dc,
title = "Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission",
abstract = "Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged ",
keywords = "Bipolar depression, High-sensitivity C-reactive protein (hs-CRP), Inflammation, Interleukin-1 receptor antagonist (IL-1Ra), Soluble interleukin-2 receptor (sIL-2R), Soluble tumor necrosis factor receptor 1 (sTNF-R1), sIL-6R",
author = "Tsai, {Shang Ying} and Chung, {Kuo Hsuan} and Shou-Hung Huang and Chen, {Pao Huan} and Lee, {Hsin Chien} and Kuo, {Chian Jue}",
note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons A/S. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2014",
month = dec,
day = "1",
doi = "10.1111/bdi.12240",
language = "English",
volume = "16",
pages = "800--808",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "8",
}
