@article{12ee686e024b4e5084c97ae2551302d5,
title = "Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: A cross-sectional study",
abstract = "In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 μg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 μg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (>10.96 μg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A.",
keywords = "bacterial infection, clinical epidemiology, infection control, paediatric lung disaese, pneumonia, respiratory infection",
author = "Janapatla, {Rajendra Prasad} and Hsu, {Mei Hua} and Chen, {Chyi Liang} and Wei, {Sung Hsi} and Yu, {Ming Jia} and Su, {Lin Hui} and Lin, {Tzou Yien} and Chiu, {Cheng Hsun}",
note = "Funding Information: Acknowledgements The authors thank the children and their families for participating in this research with prior consent. The authors thank for the statistical assistance and acknowledge the support from the Maintenance Project of the Center for Big Data Analytics and Statistics at Chang Gung Memorial Hospital for statistical consultation and data analysis. Contributors C-HC conceived and designed the study. M-HH, S-HW and M-JY carried out the experiments. RPJ, M-HH, C-LC, S-HW, M-JY, L-HS, T-YL and C-HC performed the data analysis and figure/table preparation. RPJ and C-HC reviewed the literature, interpreted data and wrote the manuscript. Funding This work was supported by Chang Gung Memorial Hospital (CMRPG3H0041, CMRPG3G1971, CMRPG3F1143 and CMRPG3F0083) and Ministry of Science and Technology (105-3011-F-182A-001), Taiwan. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2020",
month = aug,
day = "1",
doi = "10.1136/thoraxjnl-2019-213878",
language = "English",
volume = "75",
pages = "689--692",
journal = "Thorax",
issn = "0040-6376",
publisher = "BMJ Publishing Group",
number = "8",
}
