TY - JOUR
T1 - Peritoneal metastasis of glioblastoma multiforme via ventriculo-peritoneal shunt
AU - Lin, Jang Chun
AU - Liu, Wei Hsiu
AU - Ma, Hsin I.
PY - 2012/11/19
Y1 - 2012/11/19
N2 - Internal drainage of cerebrospinal fluid to the abdominal cavity via a ventriculoperitoneal shunt is commonly used for treatment of obstructive hydrocephalus. High-grade gliomas often block the natural cerebrospinal fluid pathways, but a ventriculoperitoneal shunt, as an artificial anastomosis, can provide a pathway for tumor cells to be spread with the cerebrospinal fluid. We present a 27-year-old-male diagnosed with intracranial glioblastoma multiforme. The patient had abdominal distension, poor appetite, and vomiting. Abdominal computed topography showed a large amount of ascites in the abdominal cavity and multiple tiny soft tissue nodules of the omentum. Endoscopic biopsy of nodules over the omentum was performed by a general surgeon. Pathologic examination revealed metastatic glioblastoma multiforme. Unfortunately, the patient died 2 months after peritoneal metastasis of glioblastoma multiforme via a ventriculoperitoneal shunt was impressed. The pattern of peritoneal metastasis seen in this patient is typical of tumors that directly seed the peritoneal cavity and implicates the ventriculoperitoneal shunt as the vehicle of extraneural spread. Although metastasis via a ventriculoperitoneal shunt is rare, the possibility should be considered if patients with glioblastoma multiforme complain of unexplained abdominal distension, increase in abdominal girth, or persistent abdominal pain.
AB - Internal drainage of cerebrospinal fluid to the abdominal cavity via a ventriculoperitoneal shunt is commonly used for treatment of obstructive hydrocephalus. High-grade gliomas often block the natural cerebrospinal fluid pathways, but a ventriculoperitoneal shunt, as an artificial anastomosis, can provide a pathway for tumor cells to be spread with the cerebrospinal fluid. We present a 27-year-old-male diagnosed with intracranial glioblastoma multiforme. The patient had abdominal distension, poor appetite, and vomiting. Abdominal computed topography showed a large amount of ascites in the abdominal cavity and multiple tiny soft tissue nodules of the omentum. Endoscopic biopsy of nodules over the omentum was performed by a general surgeon. Pathologic examination revealed metastatic glioblastoma multiforme. Unfortunately, the patient died 2 months after peritoneal metastasis of glioblastoma multiforme via a ventriculoperitoneal shunt was impressed. The pattern of peritoneal metastasis seen in this patient is typical of tumors that directly seed the peritoneal cavity and implicates the ventriculoperitoneal shunt as the vehicle of extraneural spread. Although metastasis via a ventriculoperitoneal shunt is rare, the possibility should be considered if patients with glioblastoma multiforme complain of unexplained abdominal distension, increase in abdominal girth, or persistent abdominal pain.
KW - Glioblastoma multiforme
KW - Peritoneal metastasis
KW - Ventriculo-peritoneal shunt
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M3 - Article
AN - SCOPUS:84869077510
SN - 1011-4564
VL - 32
SP - 179
EP - 182
JO - Journal of Medical Sciences (Taiwan)
JF - Journal of Medical Sciences (Taiwan)
IS - 4
ER -