Peptide ligations accelerated by N-terminal aspartate and glutamate residues

Gemma L. Thomas; Yves S.Y. Hsieh; Candy K.Y. Chun; Zheng Li Cai; Jeffrey R. Reimers; Richard J. Payne

doi:10.1021/ol2017356

Peptide ligations accelerated by N-terminal aspartate and glutamate residues

Gemma L. Thomas, Yves S.Y. Hsieh, Candy K.Y. Chun, Zheng Li Cai, Jeffrey R. Reimers, Richard J. Payne

研究成果: 雜誌貢獻 › 文章 › 同行評審

18 引文斯高帕斯（Scopus）

摘要

A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated.

原文	英語
頁（從 - 到）	4770-4773
頁數	4
期刊	Organic Letters
卷	13
發行號	18
DOIs	https://doi.org/10.1021/ol2017356
出版狀態	已發佈 - 9月 16 2011
對外發佈	是

ASJC Scopus subject areas

生物化學
物理與理論化學
有機化學

UN SDG

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10.1021/ol2017356

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引用此

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author = "Thomas, {Gemma L.} and Hsieh, {Yves S.Y.} and Chun, {Candy K.Y.} and Cai, {Zheng Li} and Reimers, {Jeffrey R.} and Payne, {Richard J.}",

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AU - Cai, Zheng Li

AU - Reimers, Jeffrey R.

AU - Payne, Richard J.

PY - 2011/9/16

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Peptide ligations accelerated by N-terminal aspartate and glutamate residues

摘要

ASJC Scopus subject areas

UN SDG

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其它文件與鏈接

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