PBX1 as a novel master regulator in cancer: Its regulation, molecular biology, and therapeutic applications

Ting Wan Kao, Hsiao Han Chen, James Lin, Tian Li Wang, Yao An Shen

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

PBX1 is a critical transcription factor at the top of various cell fate-determining pathways. In cancer, PBX1 stands at the crossroads of multiple oncogenic signaling pathways and mediates responses by recruiting a broad repertoire of downstream targets. Research thus far has corroborated the involvement of PBX1 in cancer proliferation, resisting apoptosis, tumor-associated neoangiogenesis, epithelial-mesenchymal transition (EMT) and metastasis, immune evasion, genome instability, and dysregulating cellular metabolism. Recently, our understanding of the functional regulation of the PBX1 protein has advanced, as increasing evidence has depicted a regulatory network consisting of transcriptional, post-transcriptional, and post-translational levels of control mechanisms. Furthermore, accumulating studies have supported the clinical utilization of PBX1 as a prognostic or therapeutic target in cancer. Preliminary results showed that PBX1 entails vast potential as a targetable master regulator in the treatment of cancer, particularly in those with high-risk features and resistance to other therapeutic strategies. In this review, we will explore the regulation, protein-protein interactions, molecular pathways, clinical application, and future challenges of PBX1.
原文英語
文章編號189085
期刊Biochimica et Biophysica Acta - Reviews on Cancer
1879
發行號2
DOIs
出版狀態已發佈 - 3月 2024

ASJC Scopus subject areas

  • 腫瘤科
  • 遺傳學
  • 癌症研究

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