Pathology of nasopharyngeal carcinoma. Proposal of a new histologic classification correlated with prognosis

Hey‐Chi ‐C Hsu, Chi‐Long ‐L Chen, Mow‐Ming ‐M Hsu, Tsong‐Chou ‐C Lynn, Shih‐Mien ‐M Tu, Shu‐Chen ‐C Huang

研究成果: 雜誌貢獻文章同行評審

42 引文 斯高帕斯(Scopus)

摘要

To establish a new histologic classification with better correlation with patient prognosis, the histologic features of nasopharyngeal carcinoma (NPC) were correlated with prognosis and clinical stage among 494 patients who had been followed a minimum of 5 years after initial radiotherapy. A slight modification of World Health Organization (WHO) classification by the separation of spindle cell variant from the nonkeratinizing (NK) and undifferentiated carcinomas (UD) provided a better prognostic correlation: keratinizing squamous cell carcinoma (KS), spindle cell carcinoma (SP), round cell carcinoma (RC), and mixed cell carcinoma (Mix, or NK); 5‐year survival rates were 21%, 41%, 51.8%, and 54% respectively. This prognostic distinction was further improved by dividing the three nonkeratinizing carcinomas (SP, RC, and Mix) into two subtypes each, according to the degree of cell anaplasia and pleomorphism: Type A (with marked anaplasia and/or pleomorphism), and Type B (with moderate or little anaplasia). The three Type A carcinomas had very similar 5‐year survival rates (33.3 to 38.6%), as did the three Type B carcinomas (60% to 71.8%). Therefore, a working formulation for the malignancy of NPC emerged: (1) high‐grade malignancy (KS; 5‐year survival, 21%), (2) intermediate malignancy (Type A carcinomas, 5‐year survival, 30%–40%), and (3) low‐grade malignancy (Type B carcinomas, 5‐year survival rate, 60%–72%). The prognostic distinction remained true after stratification by clinical stage. Therefore, the histologic condition of the tumor of NPC correlated with patient's prognosis. Cancer 59:945‐951, 1987.

原文英語
頁(從 - 到)945-951
頁數7
期刊Cancer
59
發行號5
DOIs
出版狀態已發佈 - 3月 1 1987

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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