Parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: A dosimetric and clinical comparison with conventional radiotherapy

Yee Min Jen, Rompin Shih, Yaoh Shiang Lin, Wan Fu Su, Chih Hung Ku, Chiou Shiung Chang, Pei Wei Shueng, Jing Min Hwang, Dai Wei Liu, Hsing Lung Chao, Hon Yi Lin, Li Ping Chang, Weng Yoon Shum, Chun Shu Lin

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31 引文 斯高帕斯(Scopus)

摘要

Background and purpose: This study examined the efficacy of parotid gland sparing of three-dimensional conformal radiotherapy (3DCRT) compared with conventional radiotherapy for NPC patients. Both the dose given to the parotids and clinical assessment of dry mouth were conducted. Materials and methods: Dry mouth was assessed for 108 patients treated with conventional technique and 72 treated with 3DCRT. Dose analysis was performed in 48 patients of the 3DCRT group. A dose of 70 Gy was given to the midplane in conventional radiotherapy and to 90% isodose volume in 3DCRT. Prognostic factors affecting the severity of dry mouth were analyzed using Generalized Estimating Equation (GEE). Results: In the 3DCRT group about 50% of the patients' parotid glands received less than 25 Gy. Parallel analysis of dry mouth shows a significant decrease in the incidence of severe xerostomia after 3DCRT. The proportion of patients without dry mouth was also significantly higher in the 3DCRT group than the conventional group at 1-3 years after completion of radiotherapy. Although 3DCRT delivered a higher dose to the tumor, it spared the parotid gland significantly better than the conventional treatment. Late toxicities were mostly similar between the 2 groups while local control in T4 patients and survival were improved for 3DCRT. Conclusion: Dosimetrically and clinically 3DCRT is better than conventional technique regarding parotid gland protection.
原文英語
頁(從 - 到)204-209
頁數6
期刊Radiotherapy and Oncology
75
發行號2
DOIs
出版狀態已發佈 - 5月 2005
對外發佈

ASJC Scopus subject areas

  • 血液學
  • 腫瘤科
  • 放射學、核子醫學和影像學

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