Parameters derived from myocardial tissue Doppler imaging associated with major events in patients with uremia

Shih Hung Hsiao, Shih Kai Lin, Wei Chen Huang, Chiu Yen Lee, Shu Hsin Yang, Kuan Rau Chiou, Chun Peng Liu

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)


Background: High cardiovascular mortality in uremic patients is still a problem. This study was designed to assess some echocardiographic parameters to predict prognosis. Methods: We enrolled 95 patients (19 with coronary arterial disease). All underwent conventional echocardiography and tissue Doppler imaging within 30 minutes before and after hemodialysis (H/D). We measured the ratio of the early-diastolic velocity of mitral inflow (E) to the early-diastolic velocity of the mitral annulus (Em). Patients received 4-year follow-up for major events (any-cause mortality and nonfatal cardiovascular events requiring hospitalization). Results: Thirteen deaths and 11 nonfatal major events occurred. The prevalence of underlying coronary arterial disease was higher in patients with major events than in others (33% vs. 7%), as was the degree of left ventricular (LV) systolic dysfunction (LV ejection fraction 46% ± 10 vs. 52% ± 8). Baseline E/Em, either pre-dialytic or post-dialytic, was significantly lower in event-free patients (pre-dialytic 9.9 ± 3.0 vs. 12.2 ± 4.0, p = 0.01; post-dialytic 9.2 ± 2.9 vs. 12.3 ± 3.6, p = 0.002). On Cox regression, factors significantly affecting outcomes were age, LV ejection fraction, LV mass index (hazard ratio [HR] = 1.021, 95% confidence interval [CI] 1.001-1.039, p = 0.021), and post-dialytic E/Em ≥12 (HR = 3.054, 95% CI 1.118-11.184, p = 0.009). Conclusion: Like LV dysfunction and LV mass index, a high post-dialytic E/Em was prognostic of major events.
頁(從 - 到)254-262
期刊Acta Cardiologica Sinica
出版狀態已發佈 - 12月 1 2007

ASJC Scopus subject areas

  • 心臟病學與心血管醫學


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