TY - JOUR
T1 - Papaverine and prostaglandin E1 gel applications for impotence
AU - Chiang, Han-Sun
AU - Kao, Y. H.
AU - Sheu, M. T.
PY - 1995
Y1 - 1995
N2 - The transdermal permeability of papaverine and prostaglandin E1 (PGE1) could be determined in vitro. A chemical scheme of passive delivery or with enhancer, as well as a physical iontophoretic transdermal delivery system were designed in the laboratory. Clinically, up to 20% papaverine base gel and 500 μg PGE1 were applied onto the genital area without any side effect. Only vascular response could be detected by ultrasound. However, immediate erection could not be obtained at the present dosage. Further research on the combination of skin absorption enhancers, the different chemical derivatives of PGE1 or a different administration route is warranted.
AB - The transdermal permeability of papaverine and prostaglandin E1 (PGE1) could be determined in vitro. A chemical scheme of passive delivery or with enhancer, as well as a physical iontophoretic transdermal delivery system were designed in the laboratory. Clinically, up to 20% papaverine base gel and 500 μg PGE1 were applied onto the genital area without any side effect. Only vascular response could be detected by ultrasound. However, immediate erection could not be obtained at the present dosage. Further research on the combination of skin absorption enhancers, the different chemical derivatives of PGE1 or a different administration route is warranted.
KW - erectile dysfunction
KW - intracavernosal vasodilating agent
KW - iontophoresis
KW - male sexual therapy
KW - transdermal delivery system
UR - http://www.scopus.com/inward/record.url?scp=0028971002&partnerID=8YFLogxK
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M3 - Short survey
C2 - 8579329
AN - SCOPUS:0028971002
SN - 0304-4602
VL - 24
SP - 767
EP - 769
JO - Annals of the Academy of Medicine Singapore
JF - Annals of the Academy of Medicine Singapore
IS - 5
ER -