Papaverine and prostaglandin E1 gel applications for impotence

Han-Sun Chiang, Y. H. Kao, M. T. Sheu

研究成果: 雜誌貢獻簡短的問卷調查同行評審

7 引文 斯高帕斯(Scopus)


The transdermal permeability of papaverine and prostaglandin E1 (PGE1) could be determined in vitro. A chemical scheme of passive delivery or with enhancer, as well as a physical iontophoretic transdermal delivery system were designed in the laboratory. Clinically, up to 20% papaverine base gel and 500 μg PGE1 were applied onto the genital area without any side effect. Only vascular response could be detected by ultrasound. However, immediate erection could not be obtained at the present dosage. Further research on the combination of skin absorption enhancers, the different chemical derivatives of PGE1 or a different administration route is warranted.

頁(從 - 到)767-769
期刊Annals of the Academy of Medicine Singapore
出版狀態已發佈 - 1995

ASJC Scopus subject areas

  • 一般醫學


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