TY - JOUR
T1 - Oxygen-implanted induced formation of oxide layer enhances blood compatibility on titanium for biomedical applications
AU - Hung, Wei Chiang
AU - Chang, Fang Mo
AU - Yang, Tzu Sen
AU - Ou, Keng Liang
AU - Lin, Che Tong
AU - Peng, Pei Wen
N1 - Funding Information:
The authors would like to express their thanks to Dr. Yu-Hao Chan and Dr. Yi-Yu Chen for their participation in the experiments. This research was financially supported by Taipei Medical University, under grant number TMU101-AE3-Y12.
Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The mechanical properties, such as the Young's modulus and hardness, of the layers were investigated using nanoindentation testing. The Ti4 + chemical state was determined to be present on oxygen-PIII-treated surfaces, which consisted of nanocrystalline TiO2 with a rutile structure. Compared with Ti substrates, the oxygen-PIII-treated surfaces exhibited decreased Young's moduli and hardness. Parameters indicating the blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time and platelet adhesion and activation, were studied in vitro. Clotting time assays indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of the Ti substrate, which was associated with decreased fibrinogen adsorption. In conclusion, the surface characteristics and the blood compatibility of Ti implants can be modified and improved using oxygen PIII.
AB - Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The mechanical properties, such as the Young's modulus and hardness, of the layers were investigated using nanoindentation testing. The Ti4 + chemical state was determined to be present on oxygen-PIII-treated surfaces, which consisted of nanocrystalline TiO2 with a rutile structure. Compared with Ti substrates, the oxygen-PIII-treated surfaces exhibited decreased Young's moduli and hardness. Parameters indicating the blood compatibility of the oxygen-PIII-treated surfaces, including the clotting time and platelet adhesion and activation, were studied in vitro. Clotting time assays indicated that the clotting time of oxygen-PIII-treated surfaces was longer than that of the Ti substrate, which was associated with decreased fibrinogen adsorption. In conclusion, the surface characteristics and the blood compatibility of Ti implants can be modified and improved using oxygen PIII.
KW - Clotting time
KW - Oxygen plasma-immersion ion implantation (oxygen PIII)
KW - Platelet activation
KW - Titanium
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U2 - 10.1016/j.msec.2016.06.024
DO - 10.1016/j.msec.2016.06.024
M3 - Article
C2 - 27524050
AN - SCOPUS:84974817479
SN - 0928-4931
VL - 68
SP - 523
EP - 529
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -