摘要
Background/Purpose: An increasing number of human immunodeficiency virus-1 (HIV-1)-discordant couples in Taiwan have been seeking fertility help. We conducted the first clinical trial in Taiwan of assisted reproductive technology (ART) using sperm washing and viral load measurement. Methods: From 2005 to 2009, we performed 22 ART cycles on 14 HIV-1-discordant couples. The sperm washing involved density gradient centrifugation followed by swim-up method. HIV-1 RNA was checked by real-time reverse transcription-polymerase chain reaction with a sensitivity of 40 copies/mL. In addition, we enrolled two other groups of ART recipients using frozen sperm to compare the clinical outcomes. Results: There were five pregnancies in the fresh cycles (23.8%) of HIV-1-discordant couples and the cumulative pregnancy per couple was 42.9% (6/14). The data were comparable with normal controls and testicular sperm extraction/microscopic epididymal sperm aspiration groups. The nine babies and the 14 women in this study showed no seroconversion. Conclusion: The preliminary data showed good ART results in HIV-1-discordant couples. Fertility services should not be withheld from individuals with HIV-1, although larger series are needed to reach conclusions about safety.
原文 | 英語 |
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頁(從 - 到) | 495-500 |
頁數 | 6 |
期刊 | Journal of the Formosan Medical Association |
卷 | 110 |
發行號 | 8 |
DOIs | |
出版狀態 | 已發佈 - 1月 1 2011 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 一般醫學