Orexins: A role in medullary sympathetic outflow

Nae J. Dun, Siok Le Dun,, Chiung Tong Chen, Ling Ling Hwang, Ernest H. Kwok, Jaw Kang Chang

研究成果: 雜誌貢獻回顧型文獻同行評審

83 引文 斯高帕斯(Scopus)


Orexin A and B, also known as hypocretin 1 and 2, are two recently isolated hypothalamic peptides. As orexin-containing neurons are strategically located in the lateral hypothalamus, which has long been suspected to play an important role in feeding behaviors, initial studies were focused on the involvement of orexins in positive food intake and energy metabolism. Recent studies implicate a more diverse biological role of orexins, which can be manifested at different level of the neuraxis. For example, canine narcolepsy, a disorder with close phenotypic similarity to human narcolepsy, is caused by a mutation of hypocretin receptor 2 gene. Results from our immunohistochemical and functional studies, which will be summarized here, suggest that the peptide acting on neurons in the rostral ventrolateral medulla augment sympathoexcitatory outflow to the spinal cord. This finding is discussed in the context of increased sympathetic activity frequently associated with obesity. Copyright (C) 2000 Elsevier Science B.V.
頁(從 - 到)65-70
期刊Regulatory Peptides
出版狀態已發佈 - 12月 22 2000

ASJC Scopus subject areas

  • 生物化學
  • 生理學
  • 內分泌
  • 臨床生物化學
  • 細胞與分子神經科學


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