@article{12c685b3926e4fb294d6409ce5cf8476,
title = "Ocular drug delivery: Role of degradable polymeric nanocarriers for ophthalmic application",
abstract = "Ocular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retention/permeation and prolong drug release in ocular tissue. Biodegradable polymers have been explored as the base polymers to prepare nanocarriers for encasing existing drugs to enhance the therapeutic effect with better tissue adherence, prolonged drug action, improved bioavailability, decreased toxicity, and targeted delivery in eye. In this review, we summarized recent studies on sustained ocular drug/gene delivery and emphasized on the nanocarriers made by biodegradable polymers such as liposome, poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we discussed the bio-distribution of these nanocarriers in the ocular tissue and their therapeutic applications in various ocular diseases.",
keywords = "Anterior, Biodegradable, Drug/gene delivery, Nanoparticles, Ocular, Polymeric, Posterior",
author = "Tsai, {Cheng Han} and Wang, {Peng Yuan} and Lin, {I. Chan} and Hu Huang and Liu, {Guei Sheung} and Tseng, {Ching Li}",
note = "Funding Information: Acknowledgments: We would like to acknowledge the grants support from the MOST and MOE, Taiwan. We also thank Chun-Hsien Chen for helping provide the schematic drawings of the eye. Funding Information: This research was funded by the Ministry of Science and Technology (MOST), Taiwan [MOST 106-2628-E-038-001-MY3], and the Ministry of Education (MOE), Taiwan under grant number [DPZ-107-21121-0-01]. The National Health and Medical Research Council of Australia [1061912], The Ophthalmic Research Institute of Australia, and The Rebecca L. Cooper Medical Research Foundation. Funding Information: Funding: This research was funded by the Ministry of Science and Technology (MOST), Taiwan [MOST 106-2628-E-038-001-MY3], and the Ministry of Education (MOE), Taiwan under grant number [DPZ-107-21121-0-01]. The National Health and Medical Research Council of Australia [1061912], The Ophthalmic Research Institute of Australia, and The Rebecca L. Cooper Medical Research Foundation. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = sep,
day = "19",
doi = "10.3390/ijms19092830",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "9",
}