Novel methodology for biocompatibility assessment in the immune privileged site: The "anterior chamber of rabbit eyes" model

The eye has long been considered an immune privileged site, along with the brain, gravid uterus and testis. The aim of this study is to develop a novel methodology for investigating the interactions between implanted biomaterials and an immune privileged site via testing in the "anterior chamber of rabbit eyes" model. A series of ophthalmic parameters derived from this model were designed to evaluate the functionality of a specific biomaterial applied in such region. From our experimental paradigm of gelatin, the feasibility of this potential testing method was validated.