Novel method to prepare biological samples using powerful magnets on TOF-SIMS analysis

Chun-Chao Chang; Chun Nan Chen; Wei Jhih Lin; Tsui Yun Lo; Shiou Ling Lei; Fu-Der Mai

doi:10.1002/sia.5148

Novel method to prepare biological samples using powerful magnets on TOF-SIMS analysis

Chun-Chao Chang, Chun Nan Chen, Wei Jhih Lin, Tsui Yun Lo, Shiou Ling Lei, Fu-Der Mai

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

摘要

Imaging with time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been shown to be a powerful analytical tool for mapping the distribution of biologically relevant small molecules (<1000 Da) on a surface. To improve the success rate of sample preparation, a device was designed to cells freeze-fracture by using powerful magnets. Quantum dots (QDs) were used to observe the changes in the cell after freeze-fracture. Then, TOF-SIMS was employed to analyze the ionic and molecular distribution in the cells associated with the disease.

原文	英語
頁（從 - 到）	248-250
頁數	3
期刊	Surface and Interface Analysis
卷	45
發行號	1
DOIs	https://doi.org/10.1002/sia.5148
出版狀態	已發佈 - 1月 2013

ASJC Scopus subject areas

化學 (全部)
凝聚態物理學
表面和介面
材料化學
表面、塗料和薄膜

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10.1002/sia.5148

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title = "Novel method to prepare biological samples using powerful magnets on TOF-SIMS analysis",

abstract = "Imaging with time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been shown to be a powerful analytical tool for mapping the distribution of biologically relevant small molecules (",

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AU - Lei, Shiou Ling

AU - Mai, Fu-Der

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Novel method to prepare biological samples using powerful magnets on TOF-SIMS analysis

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