摘要
Imaging with time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been shown to be a powerful analytical tool for mapping the distribution of biologically relevant small molecules (<1000 Da) on a surface. To improve the success rate of sample preparation, a device was designed to cells freeze-fracture by using powerful magnets. Quantum dots (QDs) were used to observe the changes in the cell after freeze-fracture. Then, TOF-SIMS was employed to analyze the ionic and molecular distribution in the cells associated with the disease.
原文 | 英語 |
---|---|
頁(從 - 到) | 248-250 |
頁數 | 3 |
期刊 | Surface and Interface Analysis |
卷 | 45 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 1月 2013 |
ASJC Scopus subject areas
- 化學 (全部)
- 凝聚態物理學
- 表面和介面
- 材料化學
- 表面、塗料和薄膜