摘要
The inhibitory effects on poly(ADP-ribose) glycohydrolase purified from human placenta of three classes of chemically defined tannins; gallotannins; ellagitannins and condensed tannins, were examined in vitro. Oligometric ellagitannins were found to be most potent inhibitors of poly(ADP-ribose) glycohydrolase, their potencies increasing with increasing number of monomeric residues (dinner <trimer <tetramer). Monomeric ellagitannins and gallotannins were less inhibitory. Condensed tannins, which consist of an epicatechin gallate oligomer without a glucose core, were not appreciably inhibitory. A structure-activity study showed that higher-order confirmations of the conjugates with glucose of hexahydroxydiphenoyl and valoneoyl groups, which are unique components of ellegitannins, cooperatively potentiated the inhibitory activity.
原文 | 英語 |
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頁(從 - 到) | 251-256 |
頁數 | 6 |
期刊 | Biochimica et Biophysica Acta - General Subjects |
卷 | 1158 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 11月 28 1993 |
ASJC Scopus subject areas
- 生物物理學
- 生物化學
- 分子生物學