Nonlinear analysis of heart rate dynamics in hyperthyroidism

Jin Long Chen, Yin Jiun Tseng, Hung Wen Chiu, Tzu Chien Hsiao, Woei Chyn Chu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Studies on the physiology of the cardiovascular system suggested that the generation of the heart rate signal is governed by nonlinear chaotic dynamics. No study investigated the nonlinear dynamics of heart rate in hyperthyroidism. We examined whether the heart rate dynamics of hyperthyroid patients is different from normal controls by the nonlinear analysis of heart rate variability (HRV) with correlation dimension (CD). Thirty-three hyperthyroid Graves' disease patients (30 females and 3 males; age 31 ± 1 years, means ± SE) and 33 sex-, age-, and body mass index-matched normal controls were recruited to receive one-channel electrocardiogram recording for 30 min. The CD, an index of complexity, was computed from the sequence of normal R-R intervals by the Grassberger and Procaccia algorithm. Compared to the normal controls, the hyperthyroid patients showed significant reductions (P <0.001) in the mean R-R interval (hyperthyroid 616 ± 15 versus control 868 ± 16 ms), the standard deviation of R-R intervals (25 ± 2 versus 54 ± 4 ms) and CD (5.02 ± 0.11 versus 6.42 ± 0.16). Our study demonstrated for the first time that hyperthyroid patients and normal controls could be distinguished by CD analysis of HRV. In addition, the decreased CD in hyperthyroid patients implies reduced complexity and impaired tolerance to cardiovascular stresses in hyperthyroidism. This finding helps to explain exercise intolerance and irritability manifested by the hyperthyroid patients.
原文英語
文章編號008
頁(從 - 到)427-437
頁數11
期刊Physiological Measurement
28
發行號4
DOIs
出版狀態已發佈 - 4月 1 2007

ASJC Scopus subject areas

  • 生理學(醫學)
  • 生物物理學
  • 生理學
  • 生物醫學工程

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