Noninvasive imaging of reporter gene expression and distribution in vivo

Kuo Hsiang Chuang, Tian Lu Cheng

研究成果: 雜誌貢獻回顧型文獻同行評審

5 引文 斯高帕斯(Scopus)


Repeated noninvasive imaging of reporter gene expression is increasingly used for monitoring the expression and location of genes and cells in experimental animals and humans. Development of transgenic animals that express reporter genes in specific tissues/organs or the whole body possess the potential for understanding the course of disease or serve as a syngenic cell/tissue/organ donor to study transplant survival in recipients. In this review, we discuss the major reporter genes used in gene therapy, cell therapy and transgenic animals, including exogenous reporters (herpes simplex virus type 1 thymidine kinase, fluorescent proteins and luciferase) and endogenous reporters (dopamine 2 receptor, transferrin receptor, sodium iodide symporter, β-glucuronidase, and antibody reporter). The clinical potential of these reporter genes is also discussed with regard to their imaging specificity and immunogenicity in humans.

頁(從 - 到)1-11
期刊Fooyin Journal of Health Sciences
出版狀態已發佈 - 2月 2010

ASJC Scopus subject areas

  • 生物醫學工程
  • 生物化學、遺傳與分子生物學 (全部)
  • 藥物發現


深入研究「Noninvasive imaging of reporter gene expression and distribution in vivo」主題。共同形成了獨特的指紋。