Nonequilibrium thermodynamic analysis of Michaelis-Menten kinetics

Chung Yuan Mou, Chung Hsien Liang

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

We developed a method of analysis of nonequilibrium steady states of chemical reaction system. The analysis is applied to systems of Michaelis-Menten type reactions. We focus our attention on the consequence of the quasi-steady-state approximation to the rate of entropy production. Under separation of time scale, the description of the complete kinetic system can be contracted to slow variables. We find that the resulting rate of entropy production can be written in a new and revealing way consisting of steady-state contribution, intermediate species-specific affinity production, and channel-mixing entropy terms. The species-specific term in entropy production is in the canonical form so that a thermodynamiclike description of far-from-equilibrium steady state becomes possible. Under the quasi-steady-state approximation, we find the rate of entropy production is first order. This applies also to more complicated models. Finally, we discuss the implications in stochastic fluctuations of the free energy of the system. The Michaelis-Menten type of reactions considered in this paper do not show the possibility in gains of power from fluctuating external environment.
原文英語
頁(從 - 到)7314-7320
頁數7
期刊The Journal of Chemical Physics
93
發行號10
DOIs
出版狀態已發佈 - 1990
對外發佈

ASJC Scopus subject areas

  • 一般物理與天文學
  • 物理與理論化學

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