TY - JOUR
T1 - Nitric oxide and upper airway
AU - Wang, H. W.
AU - Su, W. Y.
PY - 1998
Y1 - 1998
N2 - Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.
AB - Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.
KW - Nitric oxide
KW - Upper airway
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M3 - Article
AN - SCOPUS:0031703712
SN - 1019-6102
VL - 33
SP - 363
EP - 367
JO - Journal of Taiwan Otolaryngology - Head and Neck Surgery
JF - Journal of Taiwan Otolaryngology - Head and Neck Surgery
IS - 4
ER -