Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder

Ariel G. Gildengers, Kuo Hsuan Chung, Shou Hung Huang, Amy Begley, Howard J. Aizenstein, Shang Ying Tsai

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)


OBJECTIVE: The aim of the present study was to examine the long-term effects of bipolar disorder (BD) on brain structure (gray matter volumes).

METHODS: Fifty-four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted using methods developed through the Geriatric Neuroimaging Laboratory at the University of Pittsburgh (Pittsburgh, PA, USA).

RESULTS: Lower total gray matter volumes were related to longer duration of BD, even when controlling for current age and cerebrovascular accident (CVA) risk/burden. Additionally, longer exposure to antipsychotic medication was related to lower gray matter volumes. Lower hippocampal volumes were related to total years of antipsychotic agent exposure and CVA risk/burden scores. Older age was related to lower total gray matter, hippocampal, and amgydala volumes.

CONCLUSIONS: Our study of older adults with BD supports the understanding that BD is a neuroprogressive disorder with a longer duration of illness and more antipsychotic agent exposure related to lower gray matter volume.
頁(從 - 到)617-623
期刊Bipolar Disorders
出版狀態已發佈 - 9月 1 2014

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 生物精神病學


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