TY - JOUR
T1 - Negative-regulatory role of calmodulin in the expression of interferon-beta gene
AU - Lin, H. Y.
AU - Thacore, H. R.
PY - 1991
Y1 - 1991
N2 - Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
AB - Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
UR - http://www.scopus.com/inward/record.url?scp=0025999125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025999125&partnerID=8YFLogxK
M3 - Article
C2 - 1662459
AN - SCOPUS:0025999125
SN - 0393-974X
VL - 5
SP - 86
EP - 90
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
IS - 3
ER -
