摘要
The characterization of near-infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN-TA) with the average size of 50-100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN-TA-ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN-TA-ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN-TA-ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN-TA-ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN-TA-ICG in major organs. This is the first report of MSN function alized with NIR-ICG capable of optical imaging in vivo.
原文 | 英語 |
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頁(從 - 到) | 215-222 |
頁數 | 8 |
期刊 | Advanced Functional Materials |
卷 | 19 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 1月 23 2009 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 一般化學
- 一般材料科學
- 凝聚態物理學