Near-infrared mesoporous silica nanoparticles for optical imaging: Characterization and in vivo biodistribution

Chia Hung Lee, Shih Hsun Cheng, Yu Jing Wang, Yu Ching Chen, Nai Tzu Chen, Jeffrey Souris, Chin Tu Chen, Chung Yuan Mou, Chung Shi Yang, Leu Wei Lo

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295 引文 斯高帕斯(Scopus)

摘要

The characterization of near-infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN-TA) with the average size of 50-100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN-TA-ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN-TA-ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN-TA-ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN-TA-ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN-TA-ICG in major organs. This is the first report of MSN function alized with NIR-ICG capable of optical imaging in vivo.

原文英語
頁(從 - 到)215-222
頁數8
期刊Advanced Functional Materials
19
發行號2
DOIs
出版狀態已發佈 - 1月 23 2009
對外發佈

ASJC Scopus subject areas

  • 一般化學
  • 一般材料科學
  • 凝聚態物理學

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