NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis

Ding Ping Sun, Chia Chun Wu, Chia Lin Chou, Li Chin Cheng, Wen Ching Wang, Shiau Shiuan Lin, Shih Ting Hung, Yu Feng Tian, Chia Lang Fang, Kai Yuan Lin

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2 引文 斯高帕斯(Scopus)


Colorectal cancer (CRC) is one of the types of cancers with a high incidence and is ranked the 3rd among men and 2nd among women worldwide. The purpose of this study was to investigate the correlation between non-SMC condensin I complex subunit G (NCAPG) and the prognosis of CRC and its function in CRC cells. The expression of NCAPG in colorectal tissues and cells was detected by immunoblotting and immunohistochemistry. Kaplan–Meier analysis was used to analyze the correlation between NCAPG and CRC prognosis. RNAi technology was used to investigate how NCAPG inhibition affected the proliferation and migration of CRC cells. Overexpression of NCAPG was positively correlated with several clinicopathologic characteristics, including T stage (P = 0.0198), M stage (P = 0.0005), and TNM stage (P < 0.0001). Kaplan–Meier analysis showed that the overexpression of NCAPG was also negatively correlated with disease-free survival and overall survival. In the culture of CRC cells, the knockdown of NCAPG inhibited the proliferation, migration, and invasion of the cells. Meanwhile, it was also found that NCAPG knockdown could interfere with G2/M-G1 transition in the cell cycle, resulting in the inhibition of cell proliferation. The overexpression of NCAPG may serve as a candidate biomarker for CRC prognosis. NCAPG is also a potential therapeutic target for CRC.
期刊Pathology Research and Practice
出版狀態已發佈 - 1月 2023

ASJC Scopus subject areas

  • 病理學與法醫學
  • 細胞生物學


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