TY - JOUR
T1 - Nanoporous materials for biomedical devices
AU - Adiga, Shashishekar P.
AU - Curtiss, Larry A.
AU - Elam, Jeffrey W.
AU - Pellin, Michael J.
AU - Shih, Chun Che
AU - Shih, Chun Ming
AU - Lin, Shing Jong
AU - Su, Yea Yang
AU - Gittard, Shaun D.
AU - Zhang, Junping
AU - Narayan, Roger J.
N1 - Funding Information:
This work is supported in part by the U.S. Department of Energy’s Office of Basic Energy Sciences, under contract no. DE-AC02-06CH11357. Also, support from the National Institute of Biomedical Imaging and BioEngineering (5R21EB003090) is acknowledged.
PY - 2008/3
Y1 - 2008/3
N2 - Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.
AB - Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.
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U2 - 10.1007/s11837-008-0028-9
DO - 10.1007/s11837-008-0028-9
M3 - Review article
AN - SCOPUS:46949093684
SN - 1047-4838
VL - 60
SP - 26
EP - 32
JO - JOM
JF - JOM
IS - 3
ER -