Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Shan Jen Lin; Yu Tang Chin; Yih Ho; Szu Yi Chou; Yu Chen Sh Yang; André Wendindondé Nana; Kuan Wei Su; Yee Tong Lim; Kuan Wang; Sheng‐Yang Y. Lee; Ya Jung Shih; Yi Ru Chen; Jacqueline Whang-Peng; Paul J. Davis; Hung Yun Lin; Earl Fu

doi:10.1016/j.fct.2018.06.058

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Shan Jen Lin, Yu Tang Chin, Yih Ho, Szu Yi Chou, Yu Chen Sh Yang, André Wendindondé Nana, Kuan Wei Su, Yee Tong Lim, Kuan Wang, Sheng‐Yang Y. Lee, Ya Jung Shih, Yi Ru Chen, Jacqueline Whang-Peng, Paul J. Davis, Hung Yun Lin, Earl Fu

研究成果: 雜誌貢獻 › 文章 › 同行評審

18 引文斯高帕斯（Scopus）

摘要

Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

原文	英語
頁（從 - 到）	1-11
頁數	11
期刊	Food and Chemical Toxicology
卷	120
DOIs	https://doi.org/10.1016/j.fct.2018.06.058
出版狀態	已發佈 - 10月 1 2018

ASJC Scopus subject areas

食品科學
毒理學

UN SDG

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10.1016/j.fct.2018.06.058

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Lin, S. J., Chin, Y. T., Ho, Y., Chou, S. Y., Sh Yang, Y. C., Nana, A. W., Su, K. W., Lim, Y. T., Wang, K., Lee, SY. Y., Shih, Y. J., Chen, Y. R., Whang-Peng, J., Davis, P. J., Lin, H. Y., & Fu, E. (2018). Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. Food and Chemical Toxicology, 120, 1-11. https://doi.org/10.1016/j.fct.2018.06.058

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title = "Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells",

abstract = "Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.",

keywords = "NDAT, Oral cancer, PD-L1, Proliferation, Thyroxine",

author = "Lin, {Shan Jen} and Chin, {Yu Tang} and Yih Ho and Chou, {Szu Yi} and {Sh Yang}, {Yu Chen} and Nana, {Andr{\'e} Wendindond{\'e}} and Su, {Kuan Wei} and Lim, {Yee Tong} and Kuan Wang and Lee, {Sheng‐Yang Y.} and Shih, {Ya Jung} and Chen, {Yi Ru} and Jacqueline Whang-Peng and Davis, {Paul J.} and Lin, {Hung Yun} and Earl Fu",

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doi = "10.1016/j.fct.2018.06.058",

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AU - Lin, Shan Jen

AU - Chin, Yu Tang

AU - Ho, Yih

AU - Chou, Szu Yi

AU - Sh Yang, Yu Chen

AU - Nana, André Wendindondé

AU - Su, Kuan Wei

AU - Lim, Yee Tong

AU - Wang, Kuan

AU - Lee, Sheng‐Yang Y.

AU - Shih, Ya Jung

AU - Chen, Yi Ru

AU - Whang-Peng, Jacqueline

AU - Davis, Paul J.

AU - Lin, Hung Yun

AU - Fu, Earl

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

AB - Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

KW - NDAT

KW - Oral cancer

KW - PD-L1

KW - Proliferation

KW - Thyroxine

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ER -

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

摘要

ASJC Scopus subject areas

UN SDG

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