@article{737b6939580d4a1689e8ccd88f5b426f,
title = "Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells",
abstract = "Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.",
keywords = "NDAT, Oral cancer, PD-L1, Proliferation, Thyroxine",
author = "Lin, {Shan Jen} and Chin, {Yu Tang} and Yih Ho and Chou, {Szu Yi} and {Sh Yang}, {Yu Chen} and Nana, {Andr{\'e} Wendindond{\'e}} and Su, {Kuan Wei} and Lim, {Yee Tong} and Kuan Wang and Lee, {Sheng‐Yang Y.} and Shih, {Ya Jung} and Chen, {Yi Ru} and Jacqueline Whang-Peng and Davis, {Paul J.} and Lin, {Hung Yun} and Earl Fu",
note = "Funding Information: This work was supported in part by the grant of Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan (MMH-HB-10607), the “TMU Research Center of Cancer Translational Medicine” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (DP2-107-20000) and the general grants from the Ministry of Science and Technology, Taiwan (MOST104-2320-B-038-009; MOST 104-2314-B-038 -046 -MY3). Funding Information: This work was supported in part by the grant of Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan ( MMH-HB-10607 ), the “TMU Research Center of Cancer Translational Medicine” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan ( DP2-107-20000 ) and the general grants from the Ministry of Science and Technology, Taiwan ( MOST104-2320-B-038-009 ; MOST 104-2314-B-038 -046 -MY3 ). Publisher Copyright: {\textcopyright} 2018",
year = "2018",
month = oct,
day = "1",
doi = "10.1016/j.fct.2018.06.058",
language = "English",
volume = "120",
pages = "1--11",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",
}
