Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

Woan Ruoh Lee, Xiao Fang Yu, Wan Jr Syu, Max Essex, Tun Hou Lee

研究成果: 雜誌貢獻文章同行評審

45 引文 斯高帕斯(Scopus)

摘要

Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.
原文英語
頁(從 - 到)1799-1803
頁數5
期刊Journal of Virology
66
發行號3
出版狀態已發佈 - 3月 1992
對外發佈

ASJC Scopus subject areas

  • 微生物學
  • 免疫學
  • 昆蟲科學
  • 病毒學

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