@article{7ce6e616b18c49edbdddf88a49dbd1de,
title = "Multiplexed analysis of circulating IgA antibodies for SARS-CoV-2 and common respiratory pathogens in COVID-19 patients",
abstract = "Previous studies have revealed a diagnostic role of pathogen-specific IgA in respiratory infections. However, co-detection of serum specific IgA for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and common respiratory pathogens remains largely unexplored. This study utilizes a protein microarray technology for simultaneous and quantitative measurements of specific IgAs for eight different respiratory pathogens including adenovirus, respiratory syncytial virus, influenza virus type A, influenza virus type B, parainfluenza virus, mycoplasma pneumoniae, chlamydia pneumoniae, and SARS-CoV-2 in serum sample of patients with coronavirus disease 2019 (COVID-19). A total of 42 patients with COVID-19 were included and categorized into severe cases (20 cases) and nonsevere cases (22 cases). The results showed that co-detection rate of specific-IgA for SARS-CoV-2 with at least one pathogen were significantly higher in severe cases than that of nonsevere cases (72.2% vs. 46.2%, p =.014). Our study indicates that co-detection of IgA antibodies for respiratory pathogens might provide diagnostic value for the clinics and also be informative for risk stratification and disease management in patients with COVID-19.",
keywords = "circulating IgA, co-infection, COVID-19, respiratory pathogens, SARS-CoV-2",
author = "Fang, {Zhang fu} and Sun, {Bao qing} and Zhu, {Ai ru} and Lin, {Lian cheng} and Zhao, {Jin cun} and Song He and Huang, {Shau Ku} and Zhong, {Nan shan} and Liu, {Zhi gang}",
note = "Funding Information: We thank all the patients and their families involved in this study, as well as doctors, nurses, and civilians that had worked hard to fight against SARS‐CoV‐2. We would like to express great thankfulness to Dr. Bei Zhong (Qingyuan People's Hospital, Qingyuan) and Dr. Hong‐feng Liang (Yangjiang People's Hospital) for organizing the sample collection. We also thank Ms. Fu‐ju Liu and Ms. Meng Li (Shenzhen Sciarray Biotech Co., Ltd.) for providing technical supports. This study was supported by the Shenzhen Science and Technology Peacock Team Project (Grant No. KQTD20170331145453160), Key Projects of Shenzhen Science and Technology Plan (No. JSGG20200225153031960) and Shenzhen Nanshan District Pioneer Group Research Funds (Grant No. LHTD20180007). Funding Information: We thank all the patients and their families involved in this study, as well as doctors, nurses, and civilians that had worked hard to fight against SARS-CoV-2. We would like to express great thankfulness to Dr. Bei Zhong (Qingyuan People's Hospital, Qingyuan) and Dr. Hong-feng Liang (Yangjiang People's Hospital) for organizing the sample collection. We also thank Ms. Fu-ju Liu and Ms. Meng Li (Shenzhen Sciarray Biotech Co., Ltd.) for providing technical supports. This study was supported by the Shenzhen Science and Technology Peacock Team Project (Grant No. KQTD20170331145453160), Key Projects of Shenzhen Science and Technology Plan (No. JSGG20200225153031960) and Shenzhen Nanshan District Pioneer Group Research Funds (Grant No. LHTD20180007). Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",
year = "2021",
month = may,
doi = "10.1002/jmv.26829",
language = "English",
volume = "93",
pages = "3257--3260",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "John Wiley and Sons Inc.",
number = "5",
}
