Multiple roles for basement membrane proteins in cancer progression and EMT

Samarpita Banerjee, Wen-Cheng Lo, Payel Majumder, Debleena Roy, Mimosa Ghorai, Nusrat K Shaikh, Nishi Kant, Mahipal S Shekhawat, Vijaykumar Shivaji Gadekar, Suchanda Ghosh, Ercan Bursal, Faris Alrumaihi, Navneet Kumar Dubey, Sanjay Kumar, Danish Iqbal, Wael Alturaiki, Vijay Jagdish Upadhye, Niraj Kumar Jha, Abhijit Dey, Rohit Gundamaraju

研究成果: 雜誌貢獻回顧型文獻同行評審

25 引文 斯高帕斯(Scopus)

摘要

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics. DATA AVAILABILITY: Not applicable.
原文英語
頁(從 - 到)151220
期刊European Journal of Cell Biology
101
發行號2
DOIs
出版狀態已發佈 - 4月 2022

指紋

深入研究「Multiple roles for basement membrane proteins in cancer progression and EMT」主題。共同形成了獨特的指紋。

引用此