@article{1b520f99ea4c452eb1ba4be09f949a19,
title = "Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants",
abstract = "Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti–6Al–4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti–6Al–4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti–6Al–4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti–6Al–4V pores enhance the collagen-regulated mineralization.",
keywords = "Additive manufacturing, Implant, Nano X-ray Laue diffraction mapping, Small X-ray angle scattering, X-ray tomography",
author = "Tsai, {Pei I.} and Lam, {Tu Ngoc} and Wu, {Meng Huang} and Tseng, {Kuan Ying} and Chang, {Yuan Wei} and Sun, {Jui Sheng} and Li, {Yen Yao} and Lee, {Ming Hsueh} and Chen, {San Yuan} and Chang, {Chung Kai} and Su, {Chun Jen} and Lin, {Chia Hsien} and Chiang, {Ching Yu} and Ku, {Ching Shun} and Tsou, {Nien Ti} and Shih, {Shao Ju} and Wang, {Chun Chieh} and Huang, {E. Wen}",
note = "Funding Information: EWH appreciates the support from Ministry of Science and Technology Programs 104-2628-E-009-003-MY3 , 106-2811-E-009-032 , 106-2218-E-007-019 , 106-2514-S-007-004 , and 106-3011-F-002-002 , 107-3017-F-009-002 , 107-3011-F-002-002 , 107-2628-E-009-001-MY3 , and 107-2218-E-009-003 . We thank the ITRI Programs F301AR7Z50 , G301AR7Z50 , and GM5400J000TNL . Meng-Huang Wu and Yen-Yao Li were supported by the Chang Gung Memorial Hospital ( CMRPG6D0171-172) . Pei-I Tsai was supported by ITRI Program F301AR5F20 . Tu-Ngoc Lam was supported by MOST 107-2628-E-009-001-MY3 and “Center for Semiconductor Technology Research” 107W302 from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan . We greatly appreciate Dr. Yeu-Kuang Hwu at the Institute of Physics, Academia Sinica for the help of the X-ray micro-CT data collection, and the beam time and help from the National Synchrotron Radiation Research Center (NSRRC). The authors specially thank Ms. Shin-Yi Huang from the Industrial Technology Research Institute (ITRI) for preparation of bone samples. Funding Information: EWH appreciates the support from Ministry of Science and Technology Programs 104-2628-E-009-003-MY3, 106-2811-E-009-032, 106-2218-E-007-019, 106-2514-S-007-004, and 106-3011-F-002-002, 107-3017-F-009-002, 107-3011-F-002-002, 107-2628-E-009-001-MY3, and 107-2218-E-009-003. We thank the ITRI Programs F301AR7Z50, G301AR7Z50, and GM5400J000TNL. Meng-Huang Wu and Yen-Yao Li were supported by the Chang Gung Memorial Hospital (CMRPG6D0171-172). Pei-I Tsai was supported by ITRI Program F301AR5F20. Tu-Ngoc Lam was supported by MOST107-2628-E-009-001-MY3 and “Center for Semiconductor Technology Research” 107W302 from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. We greatly appreciate Dr. Yeu-Kuang Hwu at the Institute of Physics, Academia Sinica for the help of the X-ray micro-CT data collection, and the beam time and help from the National Synchrotron Radiation Research Center (NSRRC). The authors specially thank Ms. Shin-Yi Huang from the Industrial Technology Research Institute (ITRI) for preparation of bone samples. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = may,
day = "15",
doi = "10.1016/j.matchemphys.2019.03.047",
language = "English",
volume = "230",
pages = "83--92",
journal = "Materials Chemistry and Physics",
issn = "0254-0584",
publisher = "Elsevier BV",
}