MRNA decay factor AUF1 binds the internal ribosomal entry site of enterovirus 71 and inhibits virus replication

Jing Yi Lin, Mei Ling Li, Gary Brewer

研究成果: 雜誌貢獻文章同行評審

38 引文 斯高帕斯(Scopus)

摘要

AU-rich element binding factor 1 (AUF1) has a role in the replication cycles of different viruses. Here we demonstrate that AUF1 binds the internal ribosome entry site (IRES) of enterovirus 71 (EV71) and negatively regulates IRES-dependent translation. During EV71 infection, AUF1 accumulates in the cytoplasm where viral replication occurs, whereas AUF1 localizes predominantly in the nucleus in mock-infected cells. AUF1 knockdown in infected cells increases IRES activity and synthesis of viral proteins. Taken together, the results suggest that AUF1 interacts with the EV71 IRES to negatively regulate viral translation and replication.

原文英語
文章編號e103827
期刊PLoS ONE
9
發行號7
DOIs
出版狀態已發佈 - 7月 31 2014

ASJC Scopus subject areas

  • 多學科
  • 一般生物化學,遺傳學和分子生物學
  • 一般農業與生物科學

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