MPT0G612, a novel HDAC6 inhibitor, induces apoptosis and suppresses ifn-Γ-induced programmed death-ligand 1 in human colorectal carcinoma cells

Pharmacology, Toxicology and Pharmaceutical Science

• Colorectal Carcinoma 100%
• Colorectal Cancer 100%
• Histone Deacetylase 6 100%
• Programmed Death 1 Ligand 1 100%
• Malignant Neoplasm 40%
• Solid Malignant Neoplasm 20%
• Antitumor Activity 20%
• Immunogenicity 20%
• Hematologic Malignancy 20%
• Immune Checkpoint Inhibitor 20%
• Neoplasm 20%
• Histone Deacetylase 20%

Biochemistry, Genetics and Molecular Biology

• HDAC6 100%
• Autophagy 60%
• Cancer Cell 40%
• Cell Death 40%
• Apoptosis 20%
• Antineoplastic Activity 20%
• PD-L1 20%
• Immune Checkpoints 20%
• Immunogenicity 20%
• Histone Deacetylase 20%