TY - JOUR
T1 - Molecular structure of the octamer d(G-G-C-C-G-G-C-C)
T2 - modified A-DNA.
AU - Wang, A. H.
AU - Fujii, S.
AU - van Boom, J. H.
AU - Rich, A.
PY - 1982/7
Y1 - 1982/7
N2 - The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.
AB - The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.
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U2 - 10.1073/pnas.79.13.3968
DO - 10.1073/pnas.79.13.3968
M3 - Article
C2 - 6955784
AN - SCOPUS:0020158505
SN - 0027-8424
VL - 79
SP - 3968
EP - 3972
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 13
ER -