TY - JOUR
T1 - Modulation of Theta-Band Local Field Potential Oscillations Across Brain Networks With Central Thalamic Deep Brain Stimulation to Enhance Spatial Working Memory
AU - Chang, Ching Wen
AU - Lo, Yu Chun
AU - Lin, Sheng Huang
AU - Yang, Shih Hung
AU - Lin, Hui Ching
AU - Lin, Ting Chun
AU - Li, Ssu Ju
AU - Hsieh, Christine Chin jung
AU - Ro, Vina
AU - Chung, Yueh Jung
AU - Chang, Yun Chi
AU - Lee, Chi Wei
AU - Kuo, Chao Hung
AU - Chen, Shin Yuan
AU - Chen, You Yin
N1 - Funding Information:
This work was financially supported by the Ministry of Science and Technology of Taiwan under contract numbers of MOST 108-2321-B-010-008-MY2, 108-2636-E-006-010, 107-2221-E-010-021-MY2, 107-2221-E-010-011, 107-2314-B-303-004, 107-2221-E-035-083-MY2, 107-2314-B-038-098-MY3, and 106-2314-B-038-021. We are grateful for support from Master Cheng Yen, President of the Tzu-Chi Foundation. This work was partially supported by the Buddhist Tzu Chi General Hospital Intramural Project (TCRD 107-29), and Buddhist Tzu Chi Medical Foundation (TCMF-MP 108-01-03).
Publisher Copyright:
© Copyright © 2019 Chang, Lo, Lin, Yang, Lin, Lin, Li, Hsieh, Ro, Chung, Chang, Lee, Kuo, Chen and Chen.
PY - 2019/11/26
Y1 - 2019/11/26
N2 - Deep brain stimulation (DBS) is a well-established technique for the treatment of movement and psychiatric disorders through the modulation of neural oscillatory activity and synaptic plasticity. The central thalamus (CT) has been indicated as a potential target for stimulation to enhance memory. However, the mechanisms underlying local field potential (LFP) oscillations and memory enhancement by CT-DBS remain unknown. In this study, we used CT-DBS to investigate the mechanisms underlying the changes in oscillatory communication between the CT and hippocampus, both of which are involved in spatial working memory. Local field potentials (LFPs) were recorded from microelectrode array implanted in the CT, dentate gyrus, cornu ammonis (CA) region 1, and CA region 3. Functional connectivity (FC) strength was assessed by LFP–LFP coherence calculations for these brain regions. In addition, a T-maze behavioral task using a rat model was performed to assess the performance of spatial working memory. In DBS group, our results revealed that theta oscillations significantly increased in the CT and hippocampus compared with that in sham controls. As indicated by coherence, the FC between the CT and hippocampus significantly increased in the theta band after CT-DBS. Moreover, Western blotting showed that the protein expressions of the dopamine D1 and α4-nicotinic acetylcholine receptors were enhanced, whereas that of the dopamine D2 receptor decreased in the DBS group. In conclusion, the use of CT-DBS resulted in elevated theta oscillations, increased FC between the CT and hippocampus, and altered synaptic plasticity in the hippocampus, suggesting that CT-DBS is an effective approach for improving spatial working memory.
AB - Deep brain stimulation (DBS) is a well-established technique for the treatment of movement and psychiatric disorders through the modulation of neural oscillatory activity and synaptic plasticity. The central thalamus (CT) has been indicated as a potential target for stimulation to enhance memory. However, the mechanisms underlying local field potential (LFP) oscillations and memory enhancement by CT-DBS remain unknown. In this study, we used CT-DBS to investigate the mechanisms underlying the changes in oscillatory communication between the CT and hippocampus, both of which are involved in spatial working memory. Local field potentials (LFPs) were recorded from microelectrode array implanted in the CT, dentate gyrus, cornu ammonis (CA) region 1, and CA region 3. Functional connectivity (FC) strength was assessed by LFP–LFP coherence calculations for these brain regions. In addition, a T-maze behavioral task using a rat model was performed to assess the performance of spatial working memory. In DBS group, our results revealed that theta oscillations significantly increased in the CT and hippocampus compared with that in sham controls. As indicated by coherence, the FC between the CT and hippocampus significantly increased in the theta band after CT-DBS. Moreover, Western blotting showed that the protein expressions of the dopamine D1 and α4-nicotinic acetylcholine receptors were enhanced, whereas that of the dopamine D2 receptor decreased in the DBS group. In conclusion, the use of CT-DBS resulted in elevated theta oscillations, increased FC between the CT and hippocampus, and altered synaptic plasticity in the hippocampus, suggesting that CT-DBS is an effective approach for improving spatial working memory.
KW - central thalamus
KW - deep brain stimulation
KW - hippocampal theta oscillation
KW - spatial working memory
KW - synaptic plasticity
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U2 - 10.3389/fnins.2019.01269
DO - 10.3389/fnins.2019.01269
M3 - Article
AN - SCOPUS:85076672230
SN - 1662-4548
VL - 13
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 1269
ER -