@article{5c1a4dc4d1804bf09803bdb3aeaf8bf8,
title = "miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts",
abstract = "Young and aging hearts undergo different remodeling post pressure overload, but the regulator that determines responses to pressure overload at different ages remains unknown. With an angiotensin II (Ang II)-induced hypertensive model, miR-21 knockout mice (miR-21−/−) were observed regarding the effects of miR-21 on hypertension-induced cardiac remodeling in young (12 week-old) and old (50 week-old) mice. Although the aged heart represented a more significant hypertrophy and was associated with a higher expression of miR-21, Ang II-induced cardiac hypertrophy was attenuated in miR-21−/− mice. Upon results of cardiac-specific arrays in miR-21-overexpressing cardiomyocytes, we found a significant downregulation of S100a8. In both in vitro and in vivo models, miR-21/S100a8/NF-κB/NFAT pathway was observed to be associated with pressure overload-induced hypertrophic remodeling in aged hearts. To further investigate whether circulating miR-21 could be a biomarker reflecting the aged associated cardiac remodeling, we prospectively collected clinical and echocardiographic information of patients at young (<65 y/o) and old ages (≥65 y/o) with and without hypertension. Among 108 patients, aged subjects presented with a significantly higher expression of circulating miR-21, which was positively correlated with left ventricular wall thickness. Collectively, miR-21 was associated with a prominently hypertrophic response in aged hearts under pressure overload.",
keywords = "Aging, Cardiac hypertrophy, Hypertension, Mir-21, Pressure overload",
author = "Chang, {Wei Ting} and Shih, {Jhih Yuan} and Lin, {Yu Wen} and Huang, {Tzu Ling} and Chen, {Zhih Cherng} and Chen, {Chi Long} and Chu, {Jan Show} and Liu, {Ping Yen}",
note = "Funding Information: This study is supported by Chi-Mei Medical Center, National Cheng Kung University Hospital and Taipei Medical University Hospital. Wei-Ting Chang is also funded by Ministry of Science and Technology (MOST 105-2628-B-384-001-MY3) and the New Century Health Care Promotion Foundation. The grant of D111-G2512 from Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University for Ping-Yen Liu as the recipient. Publisher Copyright: {\textcopyright} 2022. Chang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited",
year = "2022",
doi = "10.18632/aging.204194",
language = "English",
volume = "14",
pages = "5925--5945",
journal = "Aging",
issn = "0002-0966",
publisher = "US Administration on Aging",
number = "14",
}