Methotrexate-conjugated AgInS2/ZnS quantum dots for optical imaging and drug delivery

Pei Jung Wu, Keng Liang Ou, Jem Kun Chen, Hsiao Ping Fang, Shin Hwa Tzing, Wei Xiang Lin, Jia Yaw Chang

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29 引文 斯高帕斯(Scopus)


The ability to conjugate drugs with quantum dots (QDs) offers excellent prospects in pharmacotherapy for the improvement of diagnosis and treatment of human diseases. Here, we report a facile strategy to prepare dual-functional nanomaterials consisting of QDs and an anticancer drug. Hydrophilic AgInS 2/ZnS QDs were obtained through an ultrasonication process by introducing the amphiphilic polymer, poly(maleic anhydride-alt-1-octadecene) (PMAO). Subsequently, the anticancer drug methotrexate (MTX) was covalently coupled to the surface of the AgInS2/ZnS QDs by carbodiimide chemistry. The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell proliferation assay indicated that these hydrophilic PMAO-coated AgInS2/ZnS QDs exhibited negligible cytotoxicity. Human cervical (HeLa) cancer cells had >80% cell viability after 24 h at concentrations of up to 300 μg/mL. Confocal laser scanning microscopy revealed that the AgInS2/ZnS QDs conjugated with MTX were taken up effectively by HeLa cells. In addition, this nanomaterial was shown to have a dose-dependent antiproliferative effect in cancer cells by the MTT assay. These important features suggest that AgInS2/ZnS QDs conjugated with MTX might be a novel candidate for cancer therapeutics and diagnosis in future.

頁(從 - 到)412-416
期刊Materials Letters
出版狀態已發佈 - 8月 1 2014

ASJC Scopus subject areas

  • 凝聚態物理學
  • 材料力學
  • 機械工業
  • 一般材料科學


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