Metformin for metabolic dysregulation in schizophrenic patients treated with olanzapine

Chun Hsin Chen, Chih Chiang Chiu, Ming Chyi Huang, Tzu Hua Wu, Hui Ching Liu, Mong Liang Lu

研究成果: 雜誌貢獻文章同行評審

47 引文 斯高帕斯(Scopus)


The second generation antipsychotic drugs, such as risperidone, olanzapine, and quetiapine, are effective in treating patients with schizophrenia and have been considered as the first line therapy. Recently, increasing attention has been drawn to the potential diabetogenic effect of these novel antipsychotics. The goal of this study was to evaluate the effect of metformin treatment on the olanzapine-induced metabolic disturbance in schizophrenic patients. Twenty-four schizophrenic subjects who had received olanzapine treatment at least 3 months were assigned to the therapy with metformin 1500 mg/day for 8 weeks. The metabolic parameters were quantitatively assessed at baseline, weeks 2, 4, and 8 by using the intravenous glucose tolerance test. After an 8-week treatment with metformin, the body weight, fasting levels of glucose, triglyceride, and insulin, insulin secretion, and insulin resistance significantly decreased. Half of study subjects with metabolic syndrome obtained improvement after the metformin trial. Subjects' psychopathological condition remained unchanged during the study period. The olanzapine-induced metabolic disturbance could be reversed after 8-week metformin treatment. Based on the results of this study, we hypothesize that metformin could modulate the effect of olanzapine-induced metabolic disturbance.

頁(從 - 到)925-931
期刊Progress in Neuro-Psychopharmacology and Biological Psychiatry
出版狀態已發佈 - 5月 15 2008

ASJC Scopus subject areas

  • 生物精神病學
  • 藥理


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