Metaraminol use during spinal anaesthesia for caesarean section: a meta-analysis of randomised controlled trials

E. Chao, H. L. Sun, S. W. Huang, J. H. Liao, P. L. Ma, H. C. Chen

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)


Introduction: During caesarean section, the use of a vasopressor is often required to achieve haemodynamic stability of the parturient. Metaraminol is a vasopressor used in this context in some countries. However, the differences between metaraminol and other vasopressors remain unclear. Methods: A search of the PubMed, Cochrane Library, and Embase databases was performed to identify randomised controlled trials comparing the use of metaraminol with other vasopressors during spinal anaesthesia at caesarean section. The selected studies were subjected to meta-analysis and risk-of-bias assessment. Results: Four randomised, controlled trials met the selection criteria and 409 parturients who underwent an elective caesarean section were included in this meta-analysis. The quality of these trials was good. Metaraminol was associated with higher umbilical arterial pH (standardised mean difference [SMD] 0.82, 95% CI 0.01 to 1.62, P=0.05); a lower incidence of fetal acidosis (RR 0.08, 95% CI 0.01–0.63, P=0.02); and a lower incidence of nausea or vomiting (RR 0.16, 95% CI 0.04 to 0.57, P=0.0005) than was ephedrine. Metaraminol resulted in higher umbilical arterial pH (SMD 0.42, 95% CI 0.15 to 0.68, P=0.002) but a higher incidence of reactive hypertension (RR 1.80, 95% CI 1.32 to 2.46, P=0.0002) than did phenylephrine. Conclusion: The results of this study showed that for spinal anaesthesia at elective caesarean section, metaraminol may be a more suitable vasopressor than ephedrine and its effects are at least not inferior to those of phenylephrine.
頁(從 - 到)42-50
期刊International Journal of Obstetric Anesthesia
出版狀態已發佈 - 1月 1 2019

ASJC Scopus subject areas

  • 婦產科
  • 麻醉與疼痛醫學


深入研究「Metaraminol use during spinal anaesthesia for caesarean section: a meta-analysis of randomised controlled trials」主題。共同形成了獨特的指紋。